Uterine Receptivity Assessed By Three Dimensional Ultrasound and Power Doppler in Women with Polycystic Ovary Syndrome Treated By Clomiphene Citrate Alone or Combined To Metformin | ||
| The Egyptian Journal of Fertility and Sterility | ||
| Article 9, Volume 15, Issue 2 - Serial Number 11106352, December 2011, Pages 38-42 PDF (1.96 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/egyfs.2011.257275 | ||
| Author | ||
| Hanan A. Ghali, Amal A. Zidan1, 2 | ||
| 11 Depatment of Obstetrics & Gynecology, Zagazig University | ||
| 22 Department of Clinical Pathology, Zagazig University | ||
| Abstract | ||
| Objective: A prospective randomized single blinded study was carried out to examine whether metformin when combined with clomiphene citrate (CC) had an added effect, if any, on uterine receptivity. Patients and Methods: Seventy seven egyptian women with polycystic ovary syndrome (PCOS) aging between 20-35 years were randomized to 2 groups received either 100 mg cc for 5 days alone, or with metformin 850mg bid throughout menstrual cycle. Three dimensional (3D) ultrasound with power Doppler examination was done on day 2 after human chorionic gonadotropin (hCG) injection for both groups and; endometrial volume, vascularization index (VI), flow index (FI), and vascularization flow index (VFI) of endometrial and subendometrial regions were measured. Results: Patients taking metformin, and those destined to be pregnant had significantly lower VI/FI/VFI in endometrial region. Corresponding decreases of values in subendometrial region were insignificant. Serum estradiol (E2) levels on day of hCG injection were significantly lower in cycles, where metformin was added. Conclusion: Metformin had significantly lowered VI/FI/VFI in early luteal phase in PCOS affected women. | ||
| Keywords | ||
| Key Words: Uterine Receptivity; Three Dimensional Ultrasound; Power Doppler; Polycystic Ovary Syndrome; Clomiphene Citrate; Metformin | ||
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