Can protein Z deficiency predict pregnancy outcome? | ||
| The Egyptian Journal of Fertility and Sterility | ||
| Article 7, Volume 16, Issue 1 - Serial Number 11106352, January 2012, Pages 23-26 PDF (1.23 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/egyfs.2012.257283 | ||
| Author | ||
| Maged Raghib, H Gouda* | ||
| Department of Obstetrics and Gynecology, Mansoura University Hospitals, Mansoura, Egypt. | ||
| Abstract | ||
| Objecive: The objective of this was to determine if preeclampsia (PE), intrauterine growth restriction “IUGR”; or intra-uterine fetal death “IUFD” are associated with changes in maternal plasma concentrations of protein Z. Methods: This is a prospective case control study which comprised of 130 pregnant women.Theyweredividedinto4groupd:Severepreeclampsiagroup(n=40),unexplained IUGR group (n=25), Unexplained IUFD group (n=25) and 40 women with normal pregnancy as a control group. Cross sectional maternal plasma protein Z concentrations were measured by a sensitive and specific immunoassay. Results: There was a statistical significant difference regarding protein Z between control group and complicated pregnancies (p=0.047). Protein Z levels were significantly lower in severe preeclamptic patients was than that of the other study groups p < 0.0001. However, there was no significant difference in the maternal plasma protein Z concentration between patients with unexplained IUGR or intrauterine fetal demise. Conclusion: Preeclampsia is associated with significantly lower maternal median plasma concentration of protein Z than normal pregnancy and also a high rate of protein Z deficiency was observed in patients with IUGR and fetal demise. | ||
| Keywords | ||
| Keywords: preeclampsia; intrauterine growth restriction; fetal demise; protein Z dependent protease inhibitor (ZPI) | ||
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