Follicular Fluid Activin A and Leptin Are Not Correlated With IVF Outcome Measures | ||
| The Egyptian Journal of Fertility and Sterility | ||
| Article 3, Volume 17, Issue 1 - Serial Number 11106352, January 2013, Pages 11-15 PDF (1.41 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/egyfs.2013.257464 | ||
| Author | ||
| Mohamed M Shaaban, Waleed S Ahmed, Iman Keshk, Hossam El Bahaie* 1, 2 | ||
| 11 Department of Obstetrics and Gynecology | ||
| 22 Department of clinical pathology, Faculty of Medicine - Suez Canal University | ||
| Abstract | ||
| Objective: The study is designed to evaluate the relationship between follicular fluid (FF) Leptin, Activin A and IVF outcome. Subjects & Methods: Prospective observational study measuring FF Leptin and Activin A in 90 patients undergoing ICSI excluding women having PCOS. FF samples collected at oocyte retrieval from follicles > 18 mm in diameter were analyzed for Leptin and Activin A using ELISA and results were correlated to ICSI outcome. Results: For the whole study population, mean FF Leptin level was 45.2 ng/ml and mean BMI was 25.3 kg/m². FF Leptin had a positive correlation with BMI. The mean FF Activin A was 880.8 pg/ml. 29/90 patients (32.2%) achieved pregnancy, 25 of them (86.2%) had more than 50% grade A embryos on Day 2 in contrast to 33 patients (54.1%) in the non-pregnant group (P <.02). FF Leptin and Activin A did not correlate to day 2 embryo quality or pregnancy outcome FF total Activin A level did not relate to FF Leptin level or number of oocytes collected. Low or high FF Activin A or Leptin levels did not affect fertilization, pregnancy or embryo quality. Conclusion: Neither FF Activin A nor FF Leptin levels can be used to predict IVF outcome measures. | ||
| Keywords | ||
| Key Words: Activin A; Leptin; follicular fluid; intracytoplasmic sperm injection; pregnancy | ||
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