Prednisolone in unexplained implantation failure: a randomized controlled clinical trial of efficacy | ||
| The Egyptian Journal of Fertility and Sterility | ||
| Article 5, Volume 19, Issue 1 - Serial Number 11106352, January 2015, Pages 28-33 PDF (1.95 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/egyfs.2015.257490 | ||
| Author | ||
| Mohamed Sayed Abdelhafez, Waleed El-refaie | ||
| Department of Obstetrics and Gynecology, Mansoura University, Mansoura, Egypt | ||
| Abstract | ||
| Objective: To evaluate of the effect of adding prednisolone to improve the outcomes of intracytoplasmic sperm injection (ICSI) in women with previous unexplained implantation failure. Materials & Methods: This is a randomized controlled study performed in Fertility Care Unit in Mansoura University Hospital and private fertility care centers, Mansoura, Egypt. The study comprised of women undergoing ICSI and has history of one or more implantation failure. All women were randomly divided into two groups; the study group received prednisolone in a dose of 20 mg/day starting from the day of oocyte retrieval while the control group received no treatment. The primary outcome was clinical pregnancy rate and the secondary outcomes were implantation rate and miscarriage rate. Results: 108 women (53 in the study group and 55 in the control group) subjected to final analysis. There was no significant difference between the study and control groups as regard the clinical pregnancy rate (45.3% vs 32.7%; P = 0.237), implantation rate (22.1% vs 15.2%; P = 0.145) and miscarriage rate (33.3% vs 33.3%; P = 1.000). Conclusion: Administration of prednisolone in the luteal phase to women with previous unexplained implantation failure does not result in significant increase in clinical pregnancy or implantation rates. | ||
| Keywords | ||
| Key Words: ICSI; Implantation failure; Prednisolone | ||
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