Sheta, T., El-mesery, A., Salama, K., El-Wakeel, N., El-Emam, O., Habib, A. (2022). Diagnostic utility of absolute neutrophil count as a new marker of spontaneous bacterial peritonitis; multicenter study. test, 6.3(3), 12-18. doi: 10.21608/mjvh.2022.257546
Tarek Sheta; Ahmed El-mesery; Kamal Salama; Niveen El-Wakeel; Ola El-Emam; Alaaudin Habib. "Diagnostic utility of absolute neutrophil count as a new marker of spontaneous bacterial peritonitis; multicenter study". test, 6.3, 3, 2022, 12-18. doi: 10.21608/mjvh.2022.257546
Sheta, T., El-mesery, A., Salama, K., El-Wakeel, N., El-Emam, O., Habib, A. (2022). 'Diagnostic utility of absolute neutrophil count as a new marker of spontaneous bacterial peritonitis; multicenter study', test, 6.3(3), pp. 12-18. doi: 10.21608/mjvh.2022.257546
Sheta, T., El-mesery, A., Salama, K., El-Wakeel, N., El-Emam, O., Habib, A. Diagnostic utility of absolute neutrophil count as a new marker of spontaneous bacterial peritonitis; multicenter study. test, 2022; 6.3(3): 12-18. doi: 10.21608/mjvh.2022.257546

Diagnostic utility of absolute neutrophil count as a new marker of spontaneous bacterial peritonitis; multicenter study

Medical Journal of Viral Hepatitis
Article 2, Volume 6.3, Issue 3, August 2022, Pages 12-18    PDF (253.76 K)
Document Type: Original article
DOI: 10.21608/mjvh.2022.257546
Authors
Tarek Sheta* 1; Ahmed El-mesery2; Kamal Salama3; Niveen El-Wakeel4; Ola El-Emam5; Alaaudin Habib1
1Internal Medicine Department, Mansoura University, Mansoura Egypt
2Tropical Medicine Department, Mansoura University, Mansoura, Egypt
3Damietta Cardiology and Gastroenterology Center, Damietta, Egypt
4Medical Microbiology and Immunology, Mansoura University, Mansoura, Egypt
5Clinical Pathology Department, Mansoura university, Egypt
Abstract
Background: Spontaneous bacterial peritonitis (SBP) is a fatal complication of liver cirrhosis with high mortality rates. The aim of this study is to investigate the diagnostic utility of absolute neutrophil count (ANC) as a non-invasive marker for SBP diagnosis.
Methods: Six hundred patients with cirrhotic ascites were included in the study. All patients underwent abdominal paracentesis and the ascitic fluid was processed for cell count and culture.
Results: Absolute neutrophil count was significantly higher in SBP versus non-SBP and in culture positive SBP versus culture negative SBP. ANC at cutoff value > 2.804 has 84% sensitivity and 78% specificity for diagnosis of SBP with positive and negative predictive values (79.4% and 83.6 respectively). At a cut-off point > 5.6, ANC is capable of differentiating culture positive SBP from culture negative SBP cases with 62.07% sensitivity and 60.87 % specificity. Increased ANC, white blood cell (WBC), C reactive protein (CRP), creatinine and decreased platelet emerged as independent risk factors for SBP development, while increased ANC, WBC and decreased platelets were independent predictors of culture positive SBP. 
Conclusion: This study demonstrates that, ANC count is simple, non-invasive diagnostic marker for SBP. Increased ANC, WBC, CRP, creatinine and decreased platelet emerged as independent risk factors for SBP development.
Keywords
Ascites; spontaneous bacterial peritonitis; absolute neutrophil count; C reactive protein; bacterial peritonitis; and liver cirrhosis
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