Abo-Hammam, R., Khattab, R., Salah, M., Hamad, S., Shabayek, S., Hanora, A. (2022). Multi-omics analysis of human gut microbiota in colorectal cancer patients. test, 6(2), 141-146. doi: 10.21608/rpbs.2022.154796.1161
Rana Hashem Abo-Hammam; Randa Hesham Khattab; Mohammed Salah; Samira Hamad; Sarah Shabayek; Amro Hanora. "Multi-omics analysis of human gut microbiota in colorectal cancer patients". test, 6, 2, 2022, 141-146. doi: 10.21608/rpbs.2022.154796.1161
Abo-Hammam, R., Khattab, R., Salah, M., Hamad, S., Shabayek, S., Hanora, A. (2022). 'Multi-omics analysis of human gut microbiota in colorectal cancer patients', test, 6(2), pp. 141-146. doi: 10.21608/rpbs.2022.154796.1161
Abo-Hammam, R., Khattab, R., Salah, M., Hamad, S., Shabayek, S., Hanora, A. Multi-omics analysis of human gut microbiota in colorectal cancer patients. test, 2022; 6(2): 141-146. doi: 10.21608/rpbs.2022.154796.1161

Multi-omics analysis of human gut microbiota in colorectal cancer patients

Records of Pharmaceutical and Biomedical Sciences
Article 11, Volume 6, Issue 2, 2022, Pages 141-146    PDF (478.73 K)
Document Type: Mini-reviews
DOI: 10.21608/rpbs.2022.154796.1161
Authors
Rana Hashem Abo-Hammam1; Randa Hesham Khattab2; Mohammed Salah3; Samira Hamad4; Sarah Shabayek4; Amro Hanora* 4
1Forensic toxicologist and narcotic expert, Forensic medicine authority, Ministry of Justice, Egypt
2Assisstant lecturer, Microbiology& Immunology department, AlSalam University, Egypt
3Department of Microbiology and Immunology, Faculty of Pharmacy, Port said University, Egypt
4Department of Microbiology and Immunology, Faculty of Pharmacy, Suez canal University, Ismailia, Egypt
Abstract
Colorectal cancer (CRC) is a critical health problem. It is the second cause of death globally and the third world’s most frequently diagnosed. Multiple evidences and suggestion imply the relationship of gut microbiota and colorectal cancer carcinogenesis. The different omics techniques like, metagenomic, metaproteomic and metabolomic approaches have led to important advances in the study of the intestinal microbiome, the host as well as the intestinal environment. Different bacterial species, proteins and metabolites have a crucial role in colorectal cancer screening, detection and recurrence. Integration of these three omics analysis in drawing attention to reveal taxonomic and functional structure of human gut microbiota in addition several protein and metabolites detection had helped in construction of microbial communities and their diversity in colorectal cancer patients and healthy controls besides that these bacterial species, metabolites and proteins could be used as a critical biomarkers candidate in colorectal cancer detection, prognosis and recurrence.
Keywords
Colorectal cancer; Metagenomic; Metaproteomic; Metabolomic; Gut microbiota
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