Hepatoprotective effects of Moringa oleifera seed oil and pumpkin seed oil on CCL4 induced hepatotoxicity in Rats | ||
| Suez Canal Veterinary Medical Journal. SCVMJ | ||
| Articles in Press, Accepted Manuscript, Available Online from 05 September 2022 | ||
| Document Type: Original Article | ||
| DOI: 10.21608/scvmj.2022.258069 | ||
| Author | ||
| Noha Sayed Abdelnaeim* | ||
| Clinical Pathology, Faculty of Veterinary Medicine, Suez Canal University, Egypt | ||
| Abstract | ||
| This study was designed to estimate the hepatoprotective and antioxidant effects of Moringa oleifera seed oil (MOSO) and pumpkin seed oil (PSO) against the hepatic toxicity induced by CCL4 in rats. Sixty male albino rats (120 ± 10 g) were randomly divided into 6 equal groups. Group 1 was the control group and was orally given corn oil once daily for 4 weeks. Group 2 was given MOSO at a dose of 0.2 ml/rat, while group 3 received PSO (300 mg/kg b. wt.) once daily for 4 weeks. Groups 4, 5, 6 received CCL4 i/p at a dose of 2.5 ml/kg b. wt. on days 13 and 14 of the experiment. Group 4 received no treatment and was designated as a positive control group, whereas groups 5 and 6 received MOSO and PSO at the same dose, route, and duration as groups 2 and 3. The results showed that oral administration of MOSO and PSO to CCL4-intoxicated rats for 4 weeks significantly reduced the elevated levels of liver enzymes and bilirubin and elevated serum levels of total protein, albumin, and globulin, as well as a significant improvement in lipid profile compared to the CCL4-intoxicated group. Furthermore, GSH and CAT levels were significantly higher in the treated groups, while MDA levels were significantly lower compared to the CCL4 intoxicated group. The histopathological examination of liver sections in rats pretreated with MOSO and PSO showed favorable changes in the degenerative changes created by CCL4. Our results propose that oral administration of Moringa oleifera and pumpkin seed oils have potent antioxidant and hepatoprotective effects against CCL4 toxicity in rats. | ||
| Keywords | ||
| carbon tetrachloride; Moringa oleifera; pumpkin seed; hepatotoxicity; rats | ||
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