Therapeutic role of intravenous mesenchymal stem cells infusion in a rat model of induced acute myocardial infarction | ||
| Zagazig University Medical Journal | ||
| Article 2, Volume 30, Issue 2, March and April 2024, Pages 317-325 PDF (1.16 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/zumj.2022.152270.2608 | ||
| Authors | ||
| Eman S. El-Shetry* 1; Adel M Salah Eldin Taha1; Aya Mahmoud Elgazzar2; Mohamed Saad El-Shetry3; Doaa Hendawy4; Eman Borai1 | ||
| 1Department of Human Anatomy and Embryology, Faculty of Medicine, Zagazig University, Zagazig, Egypt | ||
| 2Department Of Human Anatomy and Embryology, Faculty of Medicine, Zagazig, Egypt | ||
| 3Cardiology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt | ||
| 4Department of Biochemistry, Faculty of Medicine, Zagazig University, Zagazig, Egypt | ||
| Abstract | ||
| Background: Acute Myocardial Infarction (AMI) is a well-established cause of morbidity and mortality globally in spite of recent breakthroughs in medical therapy as reperfusion methods, implantable cardioverter-defibrillators, and ventricular assist devices. In myocardial infarction treatment, bone marrow-derived mesenchymal stem cells (BM-MSCs) are expected to demonstrate encouraging results. Objective: This study aimed to evaluate the feasible anti-inflammatory and antioxidant role of BM-MSCs infusion in rat model with induced myocardial infarction. Material and methods: Rats were randomized into an experimental (AMI) group induced by Adrenaline injection, and a control group. The (AMI) group was divided into 2 subgroups (AMI+PBS) and (AMI+BM-MSCs). The consequences of BM-MSCs infusion on cardiac inflammation and oxidative stress status were observed after 3 days of cell transplantation. Results: BM-MSCs transplantation reduced the production of the inflammatory cytokine (TNF-a) & oxidative stress markers (MDA), increased anti-inflammatory IL-10 & antioxidant SOD, and improved histological changes in the ischemic myocardium. Conclusion: This study provides evidence that BM-MCSs suppress oxidative stress and inflammation in cardiac tissue and relatively offer cardiac protection in AMI | ||
| Keywords | ||
| Acute Myocardial Infarction; Mesenchyme Stem Cells; Rat Model | ||
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