Effect of the albendazole on some liver and kidney function in broiler chicken. | ||
| Bulletin of Faculty of Science, Zagazig University | ||
| Article 2, Volume 2022, Issue 2, July 2022, Pages 22-28 PDF (1.8 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/bfszu.2022.109207.1110 | ||
| Author | ||
| Catherine Adiang* | ||
| Pharmacology, veterinary medicine, Zagazig university | ||
| Abstract | ||
| Abstract The present study has been done to evaluate the effect of albendazole on kidney and liver function and histopathology changes in broiler chicken. The animal were divided into three groups; Group one kept as a control non treated, group two treated with albendazole O25mg/ky orally for 21 successive day to broiler chicken, group three treated with albendazole in dose O-25 mg/kg in combination with vitamin E 100 mg/kg orally for 21 successive day to broiler chicken. The chickens were sacrificed and blood samples were collected immediately from each chicken separately in a dry clean centrifuge tube. Blood samples were centrifuged (3000rpmfor 15min) and plasma was spared to estimate the creatinine anuria and liver enzymes like AIT/AST and AIP. Tissue sections from the kidney and liver control and treated group were prepared and stained with hematoxylin eosin and observed under microscope. The present result showed significant increase in creatinine and urea concentration compared to animals. The result showed also that the treatment with albendazole caused significant increase in liver enzymes like AIT.AST, AIP activities compared to control animals. Histopathology examination of chicken kidneys revealed peritubular edema (PTE, arrow), interstitial round cell aggregation (RCA, arrow) and renal tubular degeneration (RTD, arrow) with focal early necrotic changes, also histopathology examination of chicken liver revealed dilated blood vessels (PBV) portal round cell aggregation (RCA) and biliary proliferation hyperplasia (BP) marked interstitial round cell aggregations. Hepatocellular degeneration (HCD) and individual cellular apoptosis (HCA), in chicken treated with albendazole . | ||
| Keywords | ||
| Key words: Albendazole; broiler chicken; histopathology; kidney | ||
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