Renal Failure Index and Assessment of Kidney Function in Preterm versus Full Term Neonates | ||
| Suez Canal University Medical Journal | ||
| Article 9, Volume 25, Issue 3, October 2022, Pages 96-102 PDF (325.21 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/scumj.2022.262059 | ||
| Authors | ||
| Amany W. Shehab* 1; Nouran B. Abdullah2; Naglaa E. Salem3; Enas F. Elnagar2 | ||
| 1Department of Pediatrics, Damietta Specialized Hospital | ||
| 2Department of Pediatrics, Faculty of Medicine, Suez Canal University, Egypt | ||
| 3Department of Clinical Pathology, Faculty of Medicine, Suez Canal University, Egypt | ||
| Abstract | ||
| Background:Prematurity is associated with one-third of all infant deaths. In recent years, there was increasing evidence to indicate that prematurity is an independent risk factor for chronic kidney diseases. Diagnosis of acute renal failure is difficult in neonates as many of the established clinical and biochemical parameters are unreliable in this age group. However, fractional excretion of sodium and the renal failure index was found to be the most useful in evaluating babies with renal failure. Aim:reduction of morbidities and mortalities resulting from neonatal acute renal failure. Objectives:Early detection and proper management of neonates at risk of developing renal injury either prerenal or intrinsic renal failure will protect them against injury risk. Subjects and Methods: This is a cross-sectional study, performed in the neonatal intensive care unit of Suez Canal University hospital on 80 neonates during the period from January 2019 to January 2020. Complete blood picture, C-reactive protein, serum sodium and creatinine, and urine sodium and creatinine were investigated. Results:There was significant difference between preterm and full-term neonates in hemoglobin (14.88±3.3 vs. 16.37±2.7 g/dl), platelets (204.42 vs. 249.5*103/mm3), serum creatinine (0.74 vs. 0.46 mg/dl), and serum sodium (140 vs. 138 meq/l), urinary creatinine (25 vs. 30mg/dl),Fraction excretion of sodium (FENa) (1.09 vs. 0.51) and Renal failure index (RFI) (1.6 vs. 0.69). Conclusions:Prematurity itself is a risk factor for developing kidney injury, it is commonly associated with high morbidity and mortality. The results of this study demonstrate that preterm neonates had renal failure index and fractional excretion of sodium higher than full-term neonates. | ||
| Keywords | ||
| acute renal failure; prematurity; assessment | ||
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