Could Fungal Infection be demonstrated among Some Nasal Polyposis Cases? | ||
| Suez Canal University Medical Journal | ||
| Article 8, Volume 25, Issue 3, October 2022, Pages 89-95 PDF (424.52 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/scumj.2022.262817 | ||
| Author | ||
| Reham F. Zittoon* | ||
| Department of Otorhinolaryngology, Suez Canal University Hospital, Egypt | ||
| Abstract | ||
| Background: Nasal polyposis is one of thecommon chronic inflammatory diseasesof the paranasal sinuses and nasal mucosa. Allergic fungal sinusitis (AFS) should be suspected in patients whohave sinusitis and nasal polyposis. Tissue examination can provide anaccurate diagnosis of fungal infection by studying the histomorphology of fungus. Aim: to identify the presence of fungal infection in nasal polyps’ by studying specimen histopathology. Patients and Methods: The study was designed as prospective and carried out on 96 patients with nasal polyposis and functional endoscopic sinus surgery was done for all patients. The resected tissue was processed for light microscopy with hematoxylin and eosin stain to identify the presence of fungus infection. Results: Histopathological examination for nasal polyposis revealed that 24 patients (25%) had fungus infection when staining with Periodic Acid-Schiff (PAS) revealed dense eosinophilic rounded fungal rod structures in the center of granuloma. In addition, lamina propria shows basophilic aggregates with surrounding chronic inflammation with focal granulomatous inflammation. Conclusion: The antifungal drugs could be used as adjuvant therapy in the treatment and prevention of nasal polyposis recurrence | ||
| Keywords | ||
| Polyp; Nasal; Fungus; Investigation; Histopathology | ||
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