Additive effect of L-Carnitine supplementation in improving systolic and diastolic functions in patients with dilated cardiomyopathy | ||
| Zagazig University Medical Journal | ||
| Article 8, Volume 29, Issue 3, May and June 2023, Pages 805-813 PDF (429.64 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/zumj.2022.156980.2622 | ||
| Authors | ||
| Islam Ghanem* 1; Baher Nashy1; Sally Sarhan2; Ahmed Shaker3 | ||
| 1Lecturer of Cardiology, Faculty of medicine, Zagazig university | ||
| 2Clinical pathology resident, El Ahrar teaching hospital, Zagazig, Egypt | ||
| 3Cardiology department, Faculty of medicine, Zagazig university | ||
| Abstract | ||
| Background: L-Carnitine may protect cardiac muscle against oxidative stress, hypoxia and ischemia. Objectives: The aim of this study was to assess the effect of L-Carnitine in improving systolic and diastolic function in patients with dilated cardiomyopathy. Patients and Methods: We studied 160 patients who were admitted to Critical Care Department, Zagazig University diagnosed as dilated cardiomyopathy. Study Group: Includes 80 patients who received conventional anti failure measures plus L-Carnitine. Placebo Group: Includes 80 patients who received conventional anti failure measures only. Results: Comparing the study versus placebo groups, There was statistically significant increase in EF in group I at 2 months (39.3±8% vs 33.52±4.8%, p: 0.001) and after 6 months (40.33±8% vs 34.5±4.8%, p: 0.001). Regarding GLS (- %), group I exhibited significant improvement in GLS at 2 months (16.5±2.9 vs 7.7±2.8, p: 0.001) which continued after 6 months (18.8±3.6vs 8.2±1.5, p: 0.001) respectively. Regarding E/E′ ratio, group I exhibited significant improvement in diastolic function at 2 and 6 months (p: 0.001) which continued after 6 months. There was no significant increase in levels of serum L carnitine in group I after 2 months (22.4±6.3 vs 19.4±2.5, p: 0.05) but there was significant increase in serum carnitine level after 6 months (35.8±10.1 vs 22.5±3.1, p: 0.01). There was statistically positive significant correlation between EF and L-Carnitine (r= 0.6, p=0.001). Conclusion: Adding L-Carnitine plus conventional anti failure measures to patients with cardiomyopathy provides a significant improvement in EF, GLS and E/E′ with consequent improvement in quality of life for these patients. | ||
| Keywords | ||
| L Carnitine; Systolic; Diastolic; Dilated; Cardiomyopathy | ||
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