Regioselective synthesis of N-alkylated 4,6-diaryl-2-oxonicotinonitrile | ||
| Bulletin of Faculty of Science, Zagazig University | ||
| Article 6, Volume 2022, Issue 3, October 2022, Pages 59-68 | ||
| Document Type: Original Article | ||
| DOI: 10.21608/bfszu.2022.139178.1140 | ||
| Authors | ||
| Hassan A El-Sayed* 1; Sammar ع Mohamed2; Ahmed H. Moustafa3; Aya A Aymn1 | ||
| 1Department of Chemistry, Faculty of Science, Zagazig University, | ||
| 2الزقازيق | ||
| 3Department of Chemistry, Faculty of Science, Zagazig University, Zagazig, Egypt. | ||
| Abstract | ||
| In the present work 4,6-diaryl-2-oxonicotinonitrile 1 reacts with serious of alkylating agents (ethyl bromoacetate, allyl bromide, propargyl bromide, chloroacetonitrile, chloroacetone, chloroacetic acid, epichlorohydrine, benzyl chloride, 1,3-dichloro isopropanol, 1,2-dichloroethane and 1,3-dibromopropane) by using K2CO3- NPs to form N-alkylated nicotinonitrile derivatives 2a-k. Also, the compounds 2j and 2k were reacted with another molecule of 2-oxonicotinonitrile 1 in the presence of K2CO3-NPs to afford the desired bis-pyridine ethane 4 and bi-pyridine propane 5, respectivelyIn the present work 4,6-diaryl-2-oxonicotinonitrile 1 reacts with serious of alkylating agents (ethyl bromoacetate, allyl bromide, propargyl bromide, chloroacetonitrile, chloroacetone, chloroacetic acid, epichlorohydrine, benzyl chloride, 1,3-dichloro isopropanol, 1,2-dichloroethane and 1,3-dibromopropane) by using K2CO3- NPs to form N-alkylated nicotinonitrile derivatives 2a-k. Also, the compounds 2j and 2k were reacted with another molecule of 2-oxonicotinonitrile 1 in the presence of K2CO3-NPs to afford the desired bis-pyridine ethane 4 and bi-pyridine propane 5, respectively.In the present work 4,6-diaryl-2-oxonicotinonitrile 1 reacts with serious of alkylating agents (ethyl bromoacetate, allyl bromide, propargyl bromide, chloroacetonitrile, chloroacetone, chloroacetic acid, epichlorohydrine, benzyl chloride, 1,3-dichloro isopropanol, 1,2-dichloroethane and 1,3-dibromopropane) by using K2CO3- NPs to form N-alkylated nicotinonitrile derivatives 2a-k. Also, the compounds 2j and 2k were reacted with another molecule of 2-oxonicotinonitrile 1 in the presence of K2CO3-NPs to afford the desired bis-pyridine ethane 4 and bi-pyridine propane 5, respectively. | ||
| Keywords | ||
| K2CO3 Nano-catalyst; N-alkylation; 2-oxonicotinonitrile; bis compounds | ||
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