THE ANTIBACTERIAL EFFECT OF CYSTEAMINE AND ITS COMBINATIONS WITH VARIOUS INTRACANAL MEDICATIONS AGAINST ENTEROCOCCUS FAECALIS | ||
| Egyptian Dental Journal | ||
| Article 2, Volume 68, Issue 4 - Serial Number 5, October 2022, Pages 3869-3879 PDF (779.08 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/edj.2022.140331.2120 | ||
| Authors | ||
| esraa elgammal* 1; abeer mahraan2; salma el ashry2; sarah fahmy3 | ||
| 1B.D.S., Faculty of Dentistry, Ain Shams University | ||
| 2Professor of Endodontics, Endodontic Department, Faculty of Dentistry, Ain Shams University | ||
| 3Lecturer in Endodontics, Endodontic Dep., Faculty of dentistry, Ainshams Univ. | ||
| Abstract | ||
| Background: The microbiological ecosystem is considered the main obstacle in endodontics. Therefore, canal disinfection became a great priority. Aim of the study: This study was established to assess cysteamine’s antibacterial effect against E. Faecalis and compare the improvement effect to its combination with various intracanal medicaments. Methods and Materials: Cleaning and shaping were performed on human single-rooted teeth then inoculated by E. faecalis biofilm. Samples were divided randomly into three groups: Group I to verify the maturation of E. faecalis biofilm inside the root canal using SEM. Group II were divided into four subgroups according to the intracanal medication used. Subgroup A was treated with Cysteamine. Subgroup B was treated with Chlorhexidine Cysteamine combination. Subgroup C was treated with Calcium hydroxide (CaOH) Cysteamine combination. Subgroup D was treated with Triple antibiotic paste Cysteamine combination. Group III were divided into two subgroups treated with plain gel; positive control and negative control. Samples collected from root canals were used for viable count (CFU/ml). Log transformation of the data was carried out. The statistical significance level was set at P < 0.05. Results: There was a significant difference between different groups (p < 0.001). Post hoc pairwise comparisons showed statistically significant difference between subgroups except for the CaOH Cysteamine combination subgroup and TAP Cysteamine combination subgroup. Conclusion: Cysteamine usage provides a synergistic antibacterial effect with other intracanal medications. CHX Cysteamine combination was the most effective antibacterial drug that provided effectiveness against E. faecalis. | ||
| Keywords | ||
| Cysteamine; Intracanal medication; TAP; Chlorhexidine; Calcium hydroxide | ||
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