Mohey, H., EL-Hammady, M., Shoman, A., Anwer, H. (2023). The possible protective role of oxytocin on hepatic ischemia and reperfusion injury via modulation of NADPH oxidase in adult male rats.. test, 40(Special issue (Academic)), 35-47. doi: 10.21608/bmfj.2022.164496.1677
Heba Mohey; Mohamed Samy EL-Hammady; Abeer Ahmed Shoman; Hala Anwer. "The possible protective role of oxytocin on hepatic ischemia and reperfusion injury via modulation of NADPH oxidase in adult male rats.". test, 40, Special issue (Academic), 2023, 35-47. doi: 10.21608/bmfj.2022.164496.1677
Mohey, H., EL-Hammady, M., Shoman, A., Anwer, H. (2023). 'The possible protective role of oxytocin on hepatic ischemia and reperfusion injury via modulation of NADPH oxidase in adult male rats.', test, 40(Special issue (Academic)), pp. 35-47. doi: 10.21608/bmfj.2022.164496.1677
Mohey, H., EL-Hammady, M., Shoman, A., Anwer, H. The possible protective role of oxytocin on hepatic ischemia and reperfusion injury via modulation of NADPH oxidase in adult male rats.. test, 2023; 40(Special issue (Academic)): 35-47. doi: 10.21608/bmfj.2022.164496.1677

The possible protective role of oxytocin on hepatic ischemia and reperfusion injury via modulation of NADPH oxidase in adult male rats.

Benha Medical Journal
Article 3, Volume 40, Special issue (Academic), September and October 2023, Pages 35-47    PDF (834.62 K)
Document Type: Original Article
DOI: 10.21608/bmfj.2022.164496.1677
Authors
Heba Mohey* 1; Mohamed Samy EL-Hammady2; Abeer Ahmed Shoman2; Hala Anwer2
1Physiology Department, Faculty of Medicine ,Benha University ,Benha ,Egypt
2Physiology Department, Faculty of Medicine, Benha University, Benha, Egypt
Abstract
Background: Hepatic ischemia reperfusion injury (HIRI) is considered one of the most common causes of liver damage and dysfunction. oxytocin (OT), besides its classical functions, exhibits a potent antistress, anti-inflammatory, and antioxidant effects. Aim: This study was designed to evaluate the effect of pretreatment with OT on HIRI and to determine its possible protective mechanisms, focusing on the potential role of NADPH oxidase 2 (NOX2). Methods: 28 adult Wister albino male rats divided into 4 groups: group I (control group): received saline and subjected to surgery without ischemic procedure, group II (OT group): received OT and subjected to surgery without ischemic procedure, group III (HIR group): underwent hepatic ischemia reperfusion (HIR) procedure & group IV (HIR+ OT group): received OT and underwent HIR procedure. We assessed the effect of OT on serum liver enzymes, hepatic malondialdehyde (MDA), glutathione (GSH), tumor necrosis factor alfa (TNFα), and NOX2. Results: HIR caused significant increases in serum liver enzymes, hepatic MDA, TNFα and NOX2 levels with a significant decrease in GSH level. Administration of OT caused a significant improvement in all previous parameters, these results were supported by histopathological examination. Conclusion: OT exerts hepatoprotective effect in HIR-induced liver injury even in part through NOX2.
Keywords
HIRI; Oxytocin; NADPH oxidase
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