Role of serum erythropoietin level in evaluating severity of tissue hypoxia in carbon monoxide intoxicated patients. | ||
| Mansoura Journal of Forensic Medicine and Clinical Toxicology | ||
| Article 2, Volume 31, Issue 1, January 2023, Pages 17-27 PDF (527.54 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/mjfmct.2022.159855.1051 | ||
| Authors | ||
| Eman Mahmoud* 1; Mohammed Sarhan1; Marwa Refaie2; Sayed Shehata3; Alshymaa Abdel Rahman4; Mostafa Aboelhamed1 | ||
| 1Forensic Medicine and Clinical Toxicology Department, Faculty of Medicine, Minia University | ||
| 2Pharmacology Department, Faculty of Medicine, Minia University | ||
| 3Cardiology Department, Faculty of Medicine, Minia University | ||
| 4Radiology Department, Faculty of Medicine, Minia University | ||
| Abstract | ||
| Carbon monoxide (CO) is the second most frequent environmental pollutant worldwide. Tissue hypoxia appears to be the main cause that stands behind the harmful effects of co-poisoning. This study aimed to improve the management of carbon monoxide-intoxicated patients by predicting of use of erythropoietin levels in determining the need for hyperbaric oxygen (HBO) treatment in CO-poisoned patients who were previously categorized as non-HBO needers according to COHB level that was found to be below 25%. This cross-sectional comparative study was carried out on 71 patients presented to the Poison Control Center of Minia University with a history of CO poisoning from 1st February 2020 to April 2022. Arterial blood samples were drawn for carboxyhemoglobin (COHb) level, venous blood samples were drawn on admission, and after 2 hours from patients who had COHb < 25 % for erythropoietin (EPO) value, CT and ECG were performed to all patients. We demonstrated that 23 patients had COHb > 25 %, and 48 patients had COHb < 25 %, EPO predicted the need for HBO in 17 patients after 2 hours with a sensitivity of 82.35 % and specificity of 100 %. So we concluded that EPO was a good predictor for the need for HBO in CO-poisoned patients with COHb less than 25%. | ||
| Keywords | ||
| Carbon monoxide; COHb; Hyperbaric oxygen; Erythropoietin; Hypoxia | ||
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