Pyrimidines as Anticancer and Antiviral: Synthesis & Reactions (A Review) | ||
| Journal of Advanced Pharmacy Research | ||
| Article 1, Volume 6, Issue 4, October 2022, Pages 155-180 PDF (864.94 K) | ||
| Document Type: Review Article | ||
| DOI: 10.21608/aprh.2022.144745.1180 | ||
| Authors | ||
| Samar Fatahala; Mosaad Mohamed; Marwa Khodair* ; Rania Abd El-Hameed | ||
| Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Helwan University, Helwan, Cairo,11795, Egypt | ||
| Abstract | ||
| Background: The interest of many medicinal and organic chemists has been attracted to the synthesis of pyrimidines and their analogues due to their highly biological and medicinal properties. Objectives& Methodology: Based on these activities, this review discusses the various recent methods for the synthesis of these heterocyclic compounds during the period of 2017 to 2021 with certain two main medicinal actions. Conclusion: Pyrimidine moiety bearing compounds, are synthesized, and reacted either through one-pot synthesis or multi-step synthesis pathways, in catalytic and solvent free condition or using catalysts and solvent. | ||
| Keywords | ||
| Pyrimidines; Anticancer; Antiviral; Reactions; Synthesis | ||
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