DESIGN AND SYNTHESIS OF NOVEL TERREMIDE DERIVATIVES FOR PHARMACOLOGICAL EVALUATION | ||
| Al-Azhar Journal of Pharmaceutical Sciences | ||
| Article 5, Volume 66, Issue 2, September and October 2022, Pages 87-98 PDF (365.14 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ajps.2022.268386 | ||
| Authors | ||
| Mohamed Elsebaei* 1; Ahmed Mancy1; Abdelrahman Mayhoub2; Mohamed Ayman3 | ||
| 1Department of Pharmaceutical Organic Chemistry, College of Pharmacy(boys), Al-Azhar University, Cairo 11884, Egypt. | ||
| 2Department of Pharmaceutical Organic Chemistry, College of Pharmacy(boys), Al-Azhar University, Cairo 11884, Egypt. Nanoscience Program, University of Science and Technology, Zewail City of Science and Technology, Giza, Egypt | ||
| 3Department of Pharmaceutical Medicinal Chemistry & Drug Design Department, College of Pharmacy(boys), Al-Azhar University, Cairo 11884, Egypt. | ||
| Abstract | ||
| clinicians and chemists are directed in those days toward the biologically active compounds to reduce the mortality and morbidity. Quinazolines were reported previously as a scaffold that possesses antitumor and antimicrobial activities. Close inspection of the structure-activity-relationships (SAR) of quinazolines revealed important structural features necessary for their antimicrobial activity: a nitrogenous ring and a side chain. Using quinazoline heterocyclic compound to try to synthesize compounds similar to terremide to enhance the activity. In the present work, advantageous moieties have been combined together to generate new hybrid scaffolds of quinazoline with the objective of synthesizing new moieties enhancing the antimicrobial biological activityand drug-like properties. | ||
| Keywords | ||
| quinazoline; terramide; MRSA; antimicrobial resistance; antitumor | ||
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