Abdelrazek, M., Nageb, A., Elbaz, R., Abouzid, A., Barakat, L. (2023). Circulating proteins as diagnostic breast cancer biomarkerss. test, 4(2), 221-234. doi: 10.21608/ajbas.2022.165656.1128
Mohamed A. Abdelrazek; Ahmed Nageb; Rizk Elbaz; Amr Abouzid; Lamiaa Barakat. "Circulating proteins as diagnostic breast cancer biomarkerss". test, 4, 2, 2023, 221-234. doi: 10.21608/ajbas.2022.165656.1128
Abdelrazek, M., Nageb, A., Elbaz, R., Abouzid, A., Barakat, L. (2023). 'Circulating proteins as diagnostic breast cancer biomarkerss', test, 4(2), pp. 221-234. doi: 10.21608/ajbas.2022.165656.1128
Abdelrazek, M., Nageb, A., Elbaz, R., Abouzid, A., Barakat, L. Circulating proteins as diagnostic breast cancer biomarkerss. test, 2023; 4(2): 221-234. doi: 10.21608/ajbas.2022.165656.1128

Circulating proteins as diagnostic breast cancer biomarkerss

Alfarama Journal of Basic & Applied Sciences
Article 3, Volume 4, Issue 2, April 2023, Pages 221-234
Document Type: Review Article
DOI: 10.21608/ajbas.2022.165656.1128
Authors
Mohamed A. Abdelrazek* 1; Ahmed Nageb2; Rizk Elbaz3; Amr Abouzid4; Lamiaa Barakat5
1Research and Development Department, Biotechnology Research Center, New Damietta, Egypt
2Department of Chemistry, Faculty of Science, Port Said University, Egypt
3Genetics Unit, Faculty of Medicine, Mansoura University, Egypt
4Department of Surgical Oncology, Oncology Centre, Faculty of Medicine, Mansoura University, Mansoura, Egypt
5Chemistry department, Science College,Portsaid University
Abstract
Abstract
In women, breast cancer (BC) is the most frequently cancer and among the leading causes of cancer-related death. Breast cancer is heterogeneous tumors group with varied molecular and morphological subtypes, making disease detection and patient outcomes evolution difficult. So, biomarkers are required to aim pathologists choose and apply the best therapy for each patient. For the last decades, reports have increasingly regarding biomarkers in liquid body fluids. Blood proteins, circulating components or secreted by cancers, are attributed to several biological functions and are an important tumor biomarkers source. These blood proteins (extracted from plasma or serum) can be used for minimally invasive, easy, simple and inexpensive determination of cancer risk, disease progression, prognostication and monitoring, treatment adjusting and early diagnosis. In this review, we discussed the main established studies on blood proteins in breast cancer and evaluate the potential of blood proteins to be prognostic and/or predictive breast cancer biomarkers.
Keywords
Breast cancer; Diagnosis; Prognosis; Blood biomarkers; Prediction
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