Genetic Expression of High Mobility Group Box 1 in Neonatal Sepsis | ||
| Benha Medical Journal | ||
| Article 19, Volume 39, Issue 3, November and December 2022, Pages 971-985 PDF (912.24 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/bmfj.2022.172219.1702 | ||
| Authors | ||
| Omima mohamed Abdel Haie1; Mona Elwahab Abd Elbeshery2; Salwa Shabaan Husein* 3; Neveen Tawfik Abed4 | ||
| 1paediatric department ,Benha faculty of medicine,benha university,egypt | ||
| 2Department of Pediatrics, Faculty of Medicine, Benha University, Egypt | ||
| 3Department of Pediatrics Faculty of Medicine - Benha University | ||
| 4pediatric department Benha faculty of medicin Benha university | ||
| Abstract | ||
| Background High-mobility group box 1 (HMGB1) has important role in a variety of diseases, including neonatal sepsis (NS). The aim of this study is to evaluate the clinical importance of HMGB1 genetic expression in NS demonstrating its diagnostic value and detecting the effect of the disease outcome on its genetic expression. Patients and Methods This study was carried out on 100 neonates; 28 neonates with clinical sepsis and had positive blood cultures (confirmed), 22 neonates with clinical sepsis but had negative blood cultures (suspected) and 50 healthy non-infected newborns age and sex matched as controls. Results Expression of HMGB1 in newborns with confirmed NS and those with suspected NS was higher than healthy controls. Also, it was higher in newborns with confirmed NS than those with suspected NS. The sensitivity and specificity of the diagnostic value of HGMB1 were higher than that of CRP and H. score. Assessment of the HMGB1 for prognosis of the disease was evaluated by univariate analysis (p= | ||
| Keywords | ||
| neonatal sepsis; high mobility group box 1; HMGB1; real-time PCR; gene expression | ||
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