Alsobeai, S., Hamad, A., Elarabany, N. (2022). Evaluating the effect of Moringa peregrina (Forssk.) Fiori seeds on some biochemical and oxidative stress markers of obese experimental rats.. test, 12(1), 156-162. doi: 10.21608/sjdfs.2022.269862
Sanad M. Alsobeai; Abeer Hamad; Naglaa Elarabany. "Evaluating the effect of Moringa peregrina (Forssk.) Fiori seeds on some biochemical and oxidative stress markers of obese experimental rats.". test, 12, 1, 2022, 156-162. doi: 10.21608/sjdfs.2022.269862
Alsobeai, S., Hamad, A., Elarabany, N. (2022). 'Evaluating the effect of Moringa peregrina (Forssk.) Fiori seeds on some biochemical and oxidative stress markers of obese experimental rats.', test, 12(1), pp. 156-162. doi: 10.21608/sjdfs.2022.269862
Alsobeai, S., Hamad, A., Elarabany, N. Evaluating the effect of Moringa peregrina (Forssk.) Fiori seeds on some biochemical and oxidative stress markers of obese experimental rats.. test, 2022; 12(1): 156-162. doi: 10.21608/sjdfs.2022.269862

Evaluating the effect of Moringa peregrina (Forssk.) Fiori seeds on some biochemical and oxidative stress markers of obese experimental rats.

Scientific Journal for Damietta Faculty of Science
Volume 12, Issue 1, 2022, Pages 156-162    PDF (441.31 K)
Document Type: Original articles
DOI: 10.21608/sjdfs.2022.269862
Authors
Sanad M. Alsobeai1; Abeer Hamad1; Naglaa Elarabany* 2
1Biology department, Sajir college of Arts and Science, Shaqra University, Saudi Arabia
2Associate professor faculty of science, Damietta University. Biology department, Sajir college of Arts and Science, Shaqra University, Saudi Arabia
Abstract
Obesity is a primary reason for morbidity and mortality. The current study aimed to evaluate the anti-obesity and antioxidant effect of Moringa peregrina (MP) seeds oil in obesity-induced rats. Forty male Sprague Dawley rats were divided into four equal groups of 10 rats each. Group C (control); group OB rats were fed a high-fat diet (HFD). Group MPI: rats treated with HFD+MP seeds oil (250 mg/kg b.wt./day, orally) and group MPII. rats treated with HFD + MP seeds oil (500 mg/kg b.wt./day, orally). Blood samples were collected by the end of the experiment for determination of serum total cholesterol (TC), Triacylglycerols (TAG), high-density lipoprotein (HDL), and low-density lipoprotein (LDL), and liver functions (ALT, AST, ALP). Moreover, malondialdehyde level (MDA), superoxide dismutase and catalase activity were measured in both plasma and liver. The results showed that TC, TAG, LDL, ALP, AST, ALT and MDA were significantly higher in obese rats than in the control group. On the other hand, administration of MP seeds oil to HFD-fed rats improved oxidative stress and lipid metabolism abnormalities by ameliorating TC, TAG and liver enzyme activities. These results suggest that MP seeds oil effectively enhances obesity-associated parameters and decreases its related complications.
Keywords
peregrina; oil; ALT; MDA, SOD
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