Cognitive decline in patients of breast cancer at Sohag University Hospital | ||
| Sohag Medical Journal | ||
| Volume 27, Issue 1, 2023, Pages 1-5 PDF (546.84 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/smj.2022.154593.1338 | ||
| Authors | ||
| manar hamza sayed* 1; Gharib Fawi Mohamed2; Hazem K. Ibrahim3; Mohamed Nasrelden Thabet4 | ||
| 1sohag faculty of medicine | ||
| 2Department of Neurology, Sohag University | ||
| 3Department of Neurology, Faculty of Medicine, Sohag University. | ||
| 4Department of neurology, Faculty of Medicine, Sohag Univertsity, Sohag, Egypt | ||
| Abstract | ||
| Abstract Cognitive decline in breast cancer patients can occur treatment related or non-treatment related. Disturbance of cognition can occur before start of any cancer therapy or in association with breast cancer therapy (e.g., radiation, hormonal therapy). Risk factors include a patient’s characteristics, such as psychological and genetic parameters other than the impact of cancer and cancer therapy. Incidence of cognitive disturbance in patients who receive chemotherapy is higher than patients receiving hormonal therapy, according to several surveys. Hypothesis of cognitive dysfunction includes increased systemic inflammation, mitochondrial dysfunction in neurons and Oxidative damage. Symptoms of cognitive dysfunction were more frequent in women who received high-dose chemotherapy, so that cognitive impairment is considered as treatment toxicity. Cognitive dysfunction was common among breast cancer patients as a toxic effect of chemotherapy. Complex attention, executive function, learning and memory are common affected domains. Pharmacologic treatment of cognitive dysfunction includes medication for dementia but without conclusive efficacy. Also, physical exercise is considered a suitable intervention, but has not been efficiently evaluated. | ||
| Keywords | ||
| Cognitive decline; breast cancer; chemotherapy; hormonal therapy; cognitive domains | ||
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