Zaitoun, M., Sarhan, A., Ismail, A., Shazly, S., Abdou, A. (2018). DAY 3 VERSUS DAY 5 EMBRYO TRANSFER A PROSPECTIVE RANDOMIZED STUDY. test, 24(8), 128-133. doi: 10.21608/zumj.2018.271153
Mai Zaitoun; Abdulmagid Mahmoud Sarhan; Ahmed Abdelaziz Ismail; Sherin Attia Shazly; Ahmed Mahmoud Abdou. "DAY 3 VERSUS DAY 5 EMBRYO TRANSFER A PROSPECTIVE RANDOMIZED STUDY". test, 24, 8, 2018, 128-133. doi: 10.21608/zumj.2018.271153
Zaitoun, M., Sarhan, A., Ismail, A., Shazly, S., Abdou, A. (2018). 'DAY 3 VERSUS DAY 5 EMBRYO TRANSFER A PROSPECTIVE RANDOMIZED STUDY', test, 24(8), pp. 128-133. doi: 10.21608/zumj.2018.271153
Zaitoun, M., Sarhan, A., Ismail, A., Shazly, S., Abdou, A. DAY 3 VERSUS DAY 5 EMBRYO TRANSFER A PROSPECTIVE RANDOMIZED STUDY. test, 2018; 24(8): 128-133. doi: 10.21608/zumj.2018.271153

DAY 3 VERSUS DAY 5 EMBRYO TRANSFER A PROSPECTIVE RANDOMIZED STUDY

Zagazig University Medical Journal
Article 13, Volume 24, Issue 8, December 2018, Pages 128-133    PDF (270.74 K)
Document Type: Original Article
DOI: 10.21608/zumj.2018.271153
Authors
Mai Zaitoun1; Abdulmagid Mahmoud Sarhan1; Ahmed Abdelaziz Ismail2; Sherin Attia Shazly1; Ahmed Mahmoud Abdou1
1Obstetrics and gynecology Department, Faculty of Medicine, Zagazig University
2Obstetrics and gynecology Department, Faculty of Medicine, Alexandria University*
Abstract
ABSTRACT
Background: Transfer of embryos at the blastocyst stage has been associated with exceptionally high implantation rates. There are, however, only a prospective randomized studies comparing day 3 versus day 5 embryo transfers. Furthermore, the number of embryos replaced in the day 3 group transfer is often higher than the number of blastocysts replaced, thereby affecting implantation rates-Subjects & Methods: A total of 86 patients undergoing standard Intracytoplasmic sperm injection who had developed at least five 8-cell embryos, symmetrical cells and showing <11% extracellular fragmentation on day 3 were randomized for day 3 or day 5 transfer. In this prospective, randomized study the implantation and pregnancy potential of embryos transferred on day 3 or day 5 were compared-Results: There was statistically significant difference between day 3 and day 5 transfer regarding clinical pregnancy rates (29.5% versus 66.7%), implantation rates (7.9% versus 34.7%), twinning rates (2.3% versus 11.9%)-Conclusion: Higher significant difference in clinical pregnancies,implantation rate in blastocyst transfer group than cleavage transfer group so it is possible to decide on performing blastocyst transfer when having 5 or more fertilized oocytes with 8-cell embryos, symmetrical cells and showing <11% extracellularfragmentation on day 3, without risking for a transfer cancellation.
 
Keywords
blastocyst; culture; embryo; transfer
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