PHYTOCHEMICAL SCREENING AND PHARMAOCOLOGICAL EVALUATION OF TECOMA GAUDICHAUDI | ||
| Bulletin of Pharmaceutical Sciences Assiut University | ||
| Volume 45, Issue 2, December 2022, Pages 585-592 PDF (839.43 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/bfsa.2022.271489 | ||
| Authors | ||
| Alekhya Veeramaneni* 1; T. Deepan2; S. Ganapaty3 | ||
| 1Department of Pharmacognosy GIET School of Pharmacy Rajahmundry | ||
| 2Department of Pharmacognosy, GIET School of Pharmacy, NH-16, Chaitanya knowledge city, Rajamahendravaram-533296, Andhrapradesh, India | ||
| 3Department of Pharmacognosy, GITAM Institute of Pharmacy, Gandhinagar, Rushikonda, Visakhapatnam-530045, Andhrapradesh, India | ||
| Abstract | ||
| Tecoma gaudichaudi is a tropical flowering plant in the Bignoniaceae family that is used to treat diabetes. The aim of this research was to evaluate antioxidant, anti-inflammatory, and antibacterial properties. Tecoma gaudichaudi ethanolic extract had considerable antioxidant activity. Antioxidant activity was measured using the DPPH assay, the radical scavenging method, and the superoxide assay. Antibacterial activity and antifungal activity were performed by cup plate method by using Ciprofloxacin as standard for antibacterial and antifungal activity. Ethanolic extract of Tecomo gaudichaudi shows significant antibacterial effect against S. Aureus, B. Subtilis, P. vulgaris and E. coli using ciprofloxacin (50µg/ml) as standard. Three alternative methods were used to calculate IC50 values for antioxidant activity. The IC50 values for T. gaudichaudi (21 g/ml) and ascorbic acid (12 g/ml) were obtained using the DPPH technique. For anti-inflammatory studies the extracts show remarkable zone of inhibition ranging from 58.97 to 72.35 µg/ml respectively compared to standard indomethacin. Steroids, saponins, flavonoids, triterpenes, and phenols are found in preliminary phytochemical investigation. In conclusion, ethanolic extract of Tecomo gaudichaudi shows significant antioxidant, anti-inflammatory and antibacterial properties. | ||
| Keywords | ||
| DPPH; Hydroxy radical scavenging; Antibacterial; Anti-inflammatory; Tecoma gaudichaudi | ||
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