FOURIER TRANSFORM INFRARED SPECTROSCOPY FOR QUANTITATIVE DETERMINATION OF VALSARTAN IN BULK MATERIALS AND IN PHARMACEUTICAL DOSAGE FORMS | ||
| Bulletin of Pharmaceutical Sciences Assiut University | ||
| Volume 45, Issue 2, December 2022, Pages 747-760 PDF (1.09 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/bfsa.2022.271598 | ||
| Authors | ||
| Najwa Harshou* ; Saleh Trefi; Yaser Bitar | ||
| Department of Pharmaceutical Chemistry and Quality Control, Faculty of Pharmacy, University of Aleppo, Aleppo, Syria | ||
| Abstract | ||
| The present paper illustrates the potential applications of Fourier Transform Infrared Spectroscopy (FT-IR) in pharmaceutical analysis. A simple, rapid, non-destructive and green (FT-IR) spectroscopy method for quality control evaluation of valsartan was developed, using potassium bromide (KBr) as a matrix to quantify the drug in bulk pharmaceutical materials and in pharmaceutical dosage forms. The sample preparation was avoided except grinding for disk composition and excluded the use of organic solvents. Absorbance obtained for the carbonyl band (C=O) located at 1732 cm-1 was used for the development of calibration curve based on simple Beer-lambert’s law. Method validation was performed according to the International Conference on Harmonization (ICH) guidelines. Linearity, accuracy, precision, robustness and selectivity were evaluated and showed acceptable results for method validation in the concentration range of (0.5 - 2.5% w/w). The developed and validated method was suitable for the quality control analysis of valsartan in bulk materials and in pharmaceutical dosage forms. | ||
| Keywords | ||
| FT-IR; Quantitative; Absorbance | ||
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