Mohameed, T., Ramadan, H., Abdel-Latif, M., Hassan, S. (2022). THERAPEUTIC EFFICACY OF ORAL VERSUS INTRAVENOUS VITAMIN K IN PATIENTS WITH LIVER CIRRHOSIS. test, 45(2), 789-800. doi: 10.21608/bfsa.2022.271641
Tarek Refaat Mohameed; Haidi Karam-Allah Ramadan; Mohamed Mahmoud Abdel-Latif; Sahar Badr Hassan. "THERAPEUTIC EFFICACY OF ORAL VERSUS INTRAVENOUS VITAMIN K IN PATIENTS WITH LIVER CIRRHOSIS". test, 45, 2, 2022, 789-800. doi: 10.21608/bfsa.2022.271641
Mohameed, T., Ramadan, H., Abdel-Latif, M., Hassan, S. (2022). 'THERAPEUTIC EFFICACY OF ORAL VERSUS INTRAVENOUS VITAMIN K IN PATIENTS WITH LIVER CIRRHOSIS', test, 45(2), pp. 789-800. doi: 10.21608/bfsa.2022.271641
Mohameed, T., Ramadan, H., Abdel-Latif, M., Hassan, S. THERAPEUTIC EFFICACY OF ORAL VERSUS INTRAVENOUS VITAMIN K IN PATIENTS WITH LIVER CIRRHOSIS. test, 2022; 45(2): 789-800. doi: 10.21608/bfsa.2022.271641

THERAPEUTIC EFFICACY OF ORAL VERSUS INTRAVENOUS VITAMIN K IN PATIENTS WITH LIVER CIRRHOSIS

Bulletin of Pharmaceutical Sciences Assiut University
Volume 45, Issue 2, December 2022, Pages 789-800    PDF (693.18 K)
Document Type: Original Article
DOI: 10.21608/bfsa.2022.271641
Authors
Tarek Refaat Mohameed1; Haidi Karam-Allah Ramadan2; Mohamed Mahmoud Abdel-Latif3; Sahar Badr Hassan* 4
1Clinical Pharmacy Unit, Al-Rajhy Liver Hospital, Assuit, Egypt.
2Department of Tropical Medicine and Gastroenterology, Faculty of Medicine, Assuit University.
3Department of Clinical Pharmacy, Faculty of Pharmacy, Assuit University.
4Department of Clinical Pharmacy, Faculty of Pharmacy, Assuit University
Abstract
Objective: Patients with liver cirrhosis have different complications including bleeding disorders, due to vitamin K-dependent coagulation factors deficiency. Vitamin K is administered to correct bleeding complications, however the evidence for its efficacy either orally or intravenously is lacking. This study aimed to assess therapeutic role of vitamin K in cirrhotic patients.Methods: A prospective observational study was conducted on ninety liver cirrhotic patients at Al-Rajhy Liver Hospital. Patients received vitamin K orally (N= 45) or intravenously (N=  45) at doses of 10 mg/day for 3 successive days. Prothrombin time (PT), international normalization ratio (INR), serum vitamin K level, hemoglobin, liver and kidney function were assessed at baseline and after 3 days of vitamin K administration. Child-Pugh score and bleeding signs were reported. Results: After vitamin K administration, vitamin K serum level was significantly increased in the oral and the IV group. PT and INR were significantly decreased in the oral and the IV groups. Vitamin K serum level had negative significant correlation with PT (r=  -0.42, P= 0.033) and INR (r=  -0.40, P= 0.038). Conclusion: Oral and IV vitamin K administration showed similar efficacy in improving PT, INR and bleeding signs. Child B class patients more benefited from vitamin k administration than Child C class..
Keywords
Intravenous; INR; Liver cirrhosis; Oral; PT; Vitamin K
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