Study of The Protective Effect of Garlic Water Extract on Dexamethasone-Induced Hepatotoxicity and Insulin Resistance in Adult Male Albino Rats | ||
| International Journal of Medical Arts | ||
| Article 10, Volume 4, Issue 8, August 2022, Pages 2606-2618 PDF (2.01 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ijma.2022.172037.1539 | ||
| Authors | ||
| Ahmad Mohammad Farag Alkot* 1; Suhaib Alsayed Naeem2; Said S. M. M. El Sayed1; Ashraf M. M. Algendy1; Mohamed Ghazy Attia Hablas3 | ||
| 1Department of Medical Physiology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt | ||
| 2Department of Histology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt | ||
| 3Department of Histology, Faculty of Medicine [Assiut], Al-Azhar University, Assiut, Egypt | ||
| Abstract | ||
| Background: The liver has an essential role in the metabolism and detoxification of various metabolites and drugs so it is liable to injury. Long-term use of dexamethasone may cause hepatic injury and insulin resistance. Garlic contains a variety of effective compounds that exhibit antioxidant, hypo-cholesterolemic, hypoglycemic, antithrombotic, antibiotic, anticancer, as well as hypotensive activities. Objective: To study the effect of garlic water extract on hepatic toxicity and insulin resistance induced by dexamethasone in adult male albino rats. Materials and Methods: Twenty-four adult male albino rats of a local strain were divided into three equal groups, group 1 [control group], group 2 [dexamethasone-treated group], and group 3 [dexamethasone and garlic-treated group]. After two weeks from the onset of the experiment serum was isolated from blood samples for assessment of Alanine Transaminase [ALT], Aspartate Transaminase [AST], serum albumin, Alkaline Phosphatase [ALP], total bilirubin, fasting blood glucose [FBG], and Fasting insulin level. Homeostasis Model Assessment for Insulin Resistance [HOMA-IR] was then calculated. Samples of the liver were taken for histopathological studies. Results: There was a significant elevation in ALT, AST, ALP, and total bilirubin and a significant reduction in serum albumin in the dexamethasone-treated group when compared with the control group. ALT, AST, ALP, and total bilirubin significantly improved in the dexamethasone and garlic extract-treated group. Also, there was a significant elevation in FBS, insulin level, and HOMA-IR in the dexamethasone-treated group when compared with the control group. These parameters were significantly decreased in the dexamethasone and garlic extract-treated group when compared with the dexamethasone-only treated group. Conclusion: Garlic water extract showed a potential protective effect against dexamethasone-induced liver injury and insulin resistance. | ||
| Keywords | ||
| Garlic water extract; Dexamethasone; Hepatotoxicity; Insulin resistance | ||
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