Eldeeb, S., Fathy, M., Abdeltwab, R. (2022). Causes of Fever of unknown origin (FUO) in infants and children attending Assiut University Children's Hospital (AUCH). test, 89(2), 7226-7230. doi: 10.21608/ejhm.2022.273069
Safiea Abd-Elfattah Eldeeb; Mohammed Ameer Fathy; Randa Mohammed Abdeltwab. "Causes of Fever of unknown origin (FUO) in infants and children attending Assiut University Children's Hospital (AUCH)". test, 89, 2, 2022, 7226-7230. doi: 10.21608/ejhm.2022.273069
Eldeeb, S., Fathy, M., Abdeltwab, R. (2022). 'Causes of Fever of unknown origin (FUO) in infants and children attending Assiut University Children's Hospital (AUCH)', test, 89(2), pp. 7226-7230. doi: 10.21608/ejhm.2022.273069
Eldeeb, S., Fathy, M., Abdeltwab, R. Causes of Fever of unknown origin (FUO) in infants and children attending Assiut University Children's Hospital (AUCH). test, 2022; 89(2): 7226-7230. doi: 10.21608/ejhm.2022.273069

Causes of Fever of unknown origin (FUO) in infants and children attending Assiut University Children's Hospital (AUCH)

The Egyptian Journal of Hospital Medicine
Article 167, Volume 89, Issue 2, October 2022, Pages 7226-7230    PDF (727.17 K)
Document Type: Original Article
DOI: 10.21608/ejhm.2022.273069
Authors
Safiea Abd-Elfattah Eldeeb; Mohammed Ameer Fathy; Randa Mohammed Abdeltwab*
Abstract
Background: Fever of unknown origin (FUO) continues to be a diagnostic dilemma for pediatricians because it is often difficult to distinguish clinically between benign and potentially life-threatening causes. The term is best reserved for children with persistent fever >38 ˚c for which a cause could not be identified for more than 1 week.
Aim of work: to evaluate a four-stage investigative guideline for the detection of the causes of FUO among children. 
Methods: 70 children aged between 6weeeks to 15 years with FUO were enrolled for this study. Graded investigations were done ranging from routine to advanced and/or specific investigations were performed after revision of detailed history and thorough examination.
Results: outpatient investigations were done in 8.6% of the cases. The duration of FUO in this study ranged from 12 days to 8 weeks. The causes of FUO were 31.4% bacterial infection and 11.4% viral infection including Covid-19 infection in 7.1% of them, herpes simplex, and glandular fever in 3.4% of them.ENT affection was present in 4.3%, and the cardiac cause was found in 4.3% of the cases. Malignancy was encountered in 10% of the cases. In 21.4% of the cases, the cause of FUO was not diagnosed. In 10% of the cases, connective tissue disease was detected, and auto-inflammatory disease was encountered in 7.1% of the cases.
Conclusion: not all cases of FUO should be admitted to a hospital, as some of them can be diagnosed and treated on an outpatient basis,
 
Keywords
causes; FUO; infants and children
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