Value of soluble urokinase type plasminogen Activator receptor as marker for neonatal sepsis or infection | ||
| Benha Medical Journal | ||
| Article 2, Volume 40, Issue 3, November and December 2023, Pages 620-630 PDF (714.43 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/bmfj.2022.164490.1676 | ||
| Authors | ||
| Dabour Ahmed1; Alshimaa Mohammed* 2; Asmaa Elfallah3; Effat Assar4 | ||
| 1Department of Pediatrics, Faculty of Medicine Benha University. Benha, Egypt. | ||
| 2Department of Pediatrics, Faculty of Medicine, Benha University, Egypt. | ||
| 3Department of Clinical and Chemical Pathology, Faculty of Medicine, Benha University, Benha, Egypt | ||
| 4Department of Pediatrics, Faculty of Medicine, Benha University, Benha, Egypt. | ||
| Abstract | ||
| Background: Neonatal sepsis is common problem with global burden due to its related comorbidities and mortalities. Aim of the work: evaluate the clinical value of soluble urokinase type plasminogen activator receptor in the diagnosis and prognosis of neonatal sepsis. Patients and methods: The study was performed on 26 neonates with suspected or proven sepsis and 26 apparently healthy neonates with matched age and sex. All neonates were subjected to history taking, clinical examination and laboratory investigations including, complete blood picture, C-reactive protein, blood culture, and suPAR. Results: Regarding the first suPAR level, there was a statistically significant difference between the sepsis and control groups (p-value 0.001). There was a statistically significant positive correlation between suPAR levels and RR, and CRP, and negative correlation between suPAR levels and apgar scores. ROC curve analysis showed that a suPAR cutoff value of 7.1 ng/mL could be accurate diagnostic test for septic shock, With 96.2% sensitivity and 96.2% specificity (AUC, 0.96 and 95% CI, 0.88-1.00) . ROC curve analysis revealed that suPAR has 83.3% sensitivity, 85.7% specificity, 83.3% PPV, and 85.7% NPV for predicting prognosis of newborn sepsis at cut-off point > 16 ng/ml with AUC 0.86, 95% CI (0.69-1.00). Conclusions: suPAR is a powerful marker of inflammation in neonatal sepsis, which was statistically significantly increased among neonatal sepsis cases compared to control, and is a prognostic marker among these cases. SuPAR was significantly correlated with other inflammatory markers, including CRP and haematological sepsis score, also there was significantly negative correlation with apgar score. | ||
| Keywords | ||
| neonatal; sepsis; suPAR; haematological-score | ||
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