Role of Vitamin D Deficiency and Radiological Assessment in The Diagnosis of Allergic Rhinitis in Children | ||
| International Journal of Medical Arts | ||
| Article 7, Volume 4, Issue 9, September 2022, Pages 2664-2675 PDF (1.45 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ijma.2022.174014.1551 | ||
| Authors | ||
| Hebatullah Ali Zain Elabdeen Abdel alazim* 1; Seham Nabil Ramdan Abdelaziz2; Sara A. Tahoun3; Marwa Mostafa Fadel Mohamed Sonbol4 | ||
| 1Department of Otorhinolaryngology, Faculty of Medicine [for girls], Al-Azhar University, Cairo, Egypt | ||
| 2Department of Pediatrics, Faculty of Medicine [for girls], Al-Azhar University, Cairo, Egypt | ||
| 3Department of Clinical Pathology, Faculty of Medicine [for girls], Al-Azhar University, Cairo, Egypt | ||
| 4Department of Radio-diagnosis, Faculty of Medicine [for girls], Al-Azhar University, Cairo, Egypt | ||
| Abstract | ||
| Objective: Determining whether there is any correlation between vitamin D status and the intensity of the allergic rhinitis [AR]. This study examined the serum vitamin D concentrations in a group of pediatric with AR. Patients and methods: In this research, 150 children with AR and 150 unaffected kids were enrolled. Each participant's serum concentrations of vitamin D 25[OH]D and 1,25[OH]2D were observed. The relationships between the clinical features of AR and vitamin D status have been demonstrated. The occurrence of an allergy reaction, a positive multiple allergen simultaneously testing, and a serological total immunoglobulin E level [≥ 100 kU/L] were used to diagnose allergic rhinitis. For both groups, the smallest cross-sectional area on acoustic rhinometry was investigated. CT scanning nose and paranasal sinuses were used to quantify the hypertrophied inferior nasal turbinate, sinuses and nasal cavity. Results: Participants in the AR group displayed significantly decreased serum concentrations of 25[OH]D, 1,25[OH]2D, and calcium than controls [p <0.0001, p<0.001, and p < 0.0001, accordingly]. Additionally, individuals with moderate to severe AR had considerably lower average 25-OHD3 concentrations than others with mild AR [p<0.001]. In the AR group, a substantial negative relationship between average 25[OH]D concentrations were observed, total nasal symptoms rating, and total immunoglobulin E levels [r =-0.71, p =0.003, and r =-0.26, p =0.032]. Conclusion: As contrasted to the healthy participants, vitamin D insufficiency is a frequently occurrence amongst pediatric with AR. A substantial negative correlation between concentrations of vitamin D and the intensity of AR illness has been demonstrated. | ||
| Keywords | ||
| Children; Vitamin D; Allergic Rhinitis; Radiology; IgE level | ||
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