Tolba, F., Noureldin Abdelrahman, A., Badr, E., El-Shimi, O. (2023). Interleukin-37 Expression in Primary Immune Thrombocytopenia in Egyptian Patients. test, 40(3), 631-639. doi: 10.21608/bmfj.2022.170800.1694
Fetnat Mahmoud Tolba; amira Mohamed Noureldin Abdelrahman; Enas Ibrahim Badr; Ola Samir El-Shimi. "Interleukin-37 Expression in Primary Immune Thrombocytopenia in Egyptian Patients". test, 40, 3, 2023, 631-639. doi: 10.21608/bmfj.2022.170800.1694
Tolba, F., Noureldin Abdelrahman, A., Badr, E., El-Shimi, O. (2023). 'Interleukin-37 Expression in Primary Immune Thrombocytopenia in Egyptian Patients', test, 40(3), pp. 631-639. doi: 10.21608/bmfj.2022.170800.1694
Tolba, F., Noureldin Abdelrahman, A., Badr, E., El-Shimi, O. Interleukin-37 Expression in Primary Immune Thrombocytopenia in Egyptian Patients. test, 2023; 40(3): 631-639. doi: 10.21608/bmfj.2022.170800.1694

Interleukin-37 Expression in Primary Immune Thrombocytopenia in Egyptian Patients

Benha Medical Journal
Article 3, Volume 40, Issue 3, November and December 2023, Pages 631-639    PDF (458.99 K)
Document Type: Original Article
DOI: 10.21608/bmfj.2022.170800.1694
Authors
Fetnat Mahmoud Tolba1; amira Mohamed Noureldin Abdelrahman2; Enas Ibrahim Badr* 3; Ola Samir El-Shimi4
1Department of clinical & chemical pathology ., Faculty of Medicine, Benha university , Egypt
2Department of Clinical and chemical pathology Faculty of Medicine, Benha University
3M.B.B.Ch., Benha University, Egypt, Resident at Benha Fever Hospital.
4Department of Clinical and Chemical Pathology, Faculty of Medicine, Benha University, Egypt.
Abstract
Background: Immune thrombocytopenia (ITP) is a bleeding disorder mediated by the immune system in which anti-platelet antibodies prematurely destroy platelets, resulting in a decreased platelet count. One of the IL-1 cytokines; IL-37, has an effect against inflammation in cancer, inflammatory and autoimmune diseases by regulating both innate and acquired immunity.
Aim: Here, we evaluated the IL-37 gene both serum levels and gene expression in ITP children patients and correlated it with the disease severity.
Patients & Methods: Forty newly diagnosed ITP patients and forty healthy, age- and sex-matched controls participated in a case-control study. Blood IL-37 gene mRNA expression and serum IL-37 level were both identified using ELISA and RT-qPCR, respectively. Results: ITP patients had significantly elevated serum IL-37 (P= 0.006) and IL-37 gene expression (P= 0.001) than controls. Positive correlations were found between the severity of ITP and a significantly lower platelet count, as well as significantly lower serum and gene expression levels of IL-37.
Conclusion: IL-37 mRNA and serum expressions are promising biomarkers for ITP diagnosis and predictors for disease severity
Keywords
ITP; thrombocytopenia; IL-37; expression; biomarker
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