Does Latent Toxoplasmosis Impacts SARS-CoV-2 Infection Severity and Outcome?: A Cross-Sectional Study in Benha, Egypt. | ||
| Benha Medical Journal | ||
| Article 8, Volume 40, Issue 1, May and June 2023, Pages 80-96 PDF (896.72 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/bmfj.2022.174306.1705 | ||
| Authors | ||
| asmaa A elkholy* 1; ghada helmy omar2; ayman mohamed elbadawy3; rasha A omar3; amira A mohamady3; rabab ELSAYED omar2; amira essam ramadan4; Eman Mohammed Araby5; seham gouda ameen6; ahmed ezzat mansour3 | ||
| 1parasitology department ,banha faculty of medicine ,banha university, banha ,egypt | ||
| 2parasitology department ,banha faculty of medicine ,banha university, banha ,egypt | ||
| 3internal medicine department ,banha faculty of medicine ,banha university, banha ,egypt | ||
| 4microbiology department ,banha faculty of medicine ,banha university, banha ,egypt | ||
| 5assistant professor of Public health& community medicine , Benha faculty of medicine, Benha university, Benha city, Qualubia Governorate, Egypt. | ||
| 6Clinical and Chemical Pathology Faculty of Medicine, Benha University. | ||
| Abstract | ||
| Background: The unique single-stranded RNA virus COVID-19 is to blame for the initial viral pneumonia outbreak in China that quickly turned into a pandemic. The "immune exhaustion" which flares up viral multiplication and hasty clinical results, is one of the primary criteria of the immune response against COVID-19 and also, it is a common side effect of chronic infections with Toxoplasma gondii. The severity of COVID-19 could possibly be increased by the toxoplasmosis-associated immune depletion by making it worse. Aim of study: Our goal was to ascertain the prevalence of coinfection with latent toxoplasmosis in COVID 19 positive patients as well as its impact on the progression of the infection and the fate of the disease. Patients &Methods: 50 patients with PCR-comfirmed COVID-19 infection were recruited for this cross sectional cohort prospective study at benha university hospitals. They underwent Toxoplasma IgG testing by ELISA and had their conditions monitored to assess the COVID-19 infection's outcome. Results: Toxoplasma IgG seropositivity was found in 29(58%) patients while history of animal contact was 48.3% and 38.1% in both IgG positive and negative groups respectively. Toxoplasma Positive group showed higher incidence of: long hospital stay (20.7±7.3), ICU admission (72.4%), need for ventilation (55.3%), more lung affection and sever CT findings (24.1%) and higher death rate (10.3%). All these previous differences were statistically significant. Conclusion: The concurrent latent toxoplasmosis infection in (SARS-CoV-2) patients was linked to a more severe course and a worse result of COVID-19 infection. | ||
| Keywords | ||
| Keywords: COVID‐19; Parasitic infections; Toxoplasmosis | ||
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