Preparation and characterization of cellulose/poly (N-vinyl-2-pyrrolidone) hydrogels | ||
| Egyptian Journal of Chemistry | ||
| Volume 66, Issue 9, September 2023, Pages 245-255 PDF (1.55 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejchem.2022.174496.7216 | ||
| Authors | ||
| H.M. Fahmy; A.S. Montaser* | ||
| Textile Research and Technology Institute, National Research Centre, Dokki, Giza, Egypt. | ||
| Abstract | ||
| Cellulose powder / poly (N-vinyl-2-pyrrolidone) (CP/PVP) and carboxymethylcellulose / poly (N-vinyl-2-pyrrolidone) (CMC/PVP) hydrogels were synthesized at different reaction conditions using ammonium persulphate as initiator. The optimum reaction conditions to prepare such gels are PVP molecular weight (40000 Dalton), PVP concentration (60%), APS/polymers weight ratio (100%), reaction time (45 min), reaction temperature (90 OC), as well as CP/PVP or CMC/PVP weight ratio (25%). The prepared matrices were characterized via FTIR as well as scan electron microscope analysis. The release profiles of sodium diclofenac form the CP/PVP and CMC/PVP gels at pH 7 were studied. Release studies showed burst release for both matrices at first 30 min followed by sustained behavior. matrices PVP/CMC showed highest release of DS due to repulsive forces between polymer chains. | ||
| Keywords | ||
| Cellulose; PVP; CMC; drug release; hydrogel | ||
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