Bryozoans as a source of new antiparasitic compounds: A systematic review | ||
| Egyptian Journal of Aquatic Biology and Fisheries | ||
| Article 49, Volume 26, Issue 6, November and December 2022, Pages 839-859 PDF (909.55 K) | ||
| Document Type: Review articles | ||
| DOI: 10.21608/ejabf.2022.276519 | ||
| Author | ||
| Osama Mohammad Sayed Mostafa | ||
| Abstract | ||
| Due to the lack of effective vaccines and efficient chemotherapy against parasitic infections, the development of antiparasitic innovative medications is an urgent issue. Marine invertebrates were considered as a major source of useful pharmaceuticals. Despite the fact that there has been relatively little research on the bioactive chemicals of the sea-dwelling phylum "Bryozoa", bryozoans have proven to be a rich source of novel therapeutic compounds. In the present article, studies on the antiparasitic effects of chemicals isolated from bryozoans that have been published over the last two decades were reviewed. A total of 26 bryozoans' compounds were investigated as potential antiparasitic compounds from four different genera of Bryozoa. In vitro activities of these compounds against five parasites, Trypanosoma brucei brucei, Plasmodium falciparum, Leishmania braziliensis, Trichinella spiralis, and Haemonchus contortus were reviewed. The challenges of developing these chemicals into functional treatments, as well as the reasons for the lack of research on bryozoans' animals, were discussed in the present systematic review. | ||
| Keywords | ||
| Bryozoa; Natural products; Antiprotozoal; Anthelmintic; Antiparasitic | ||
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