Basyouni, W., Abbas, S., El-bayouki, K., El-kady, M., Abdelazeem, N., Dawood, R., Shemis, M. (2023). Cytotoxic activity of some benzo[4,5]imidazo[1,2-a]pyrimidine derivatives against the human cancer cell lines HepG2 and MCF-7. test, 66(9), 237-243. doi: 10.21608/ejchem.2023.173878.7209
Wahid Basyouni; Samir Youssef Abbas; Khairy A.M El-bayouki; Mohamed Y. El-kady; Nagwa M. Abdelazeem; Reham Dawood; Mohamed A. Shemis. "Cytotoxic activity of some benzo[4,5]imidazo[1,2-a]pyrimidine derivatives against the human cancer cell lines HepG2 and MCF-7". test, 66, 9, 2023, 237-243. doi: 10.21608/ejchem.2023.173878.7209
Basyouni, W., Abbas, S., El-bayouki, K., El-kady, M., Abdelazeem, N., Dawood, R., Shemis, M. (2023). 'Cytotoxic activity of some benzo[4,5]imidazo[1,2-a]pyrimidine derivatives against the human cancer cell lines HepG2 and MCF-7', test, 66(9), pp. 237-243. doi: 10.21608/ejchem.2023.173878.7209
Basyouni, W., Abbas, S., El-bayouki, K., El-kady, M., Abdelazeem, N., Dawood, R., Shemis, M. Cytotoxic activity of some benzo[4,5]imidazo[1,2-a]pyrimidine derivatives against the human cancer cell lines HepG2 and MCF-7. test, 2023; 66(9): 237-243. doi: 10.21608/ejchem.2023.173878.7209

Cytotoxic activity of some benzo[4,5]imidazo[1,2-a]pyrimidine derivatives against the human cancer cell lines HepG2 and MCF-7

Egyptian Journal of Chemistry
Volume 66, Issue 9, September 2023, Pages 237-243    PDF (834.75 K)
Document Type: Original Article
DOI: 10.21608/ejchem.2023.173878.7209
Authors
Wahid Basyouni1; Samir Youssef Abbas2; Khairy A.M El-bayouki3; Mohamed Y. El-kady4; Nagwa M. Abdelazeem* 5; Reham Dawood6; Mohamed A. Shemis7
1National Research Centre
2Organometalic and Organometalliod Chemistry Department, National Research Centre
3Organometallic chemistry Department, National research centre
4Ain Shams university
5Organometallic and Organometalloid Chemistry Department, National Research Centre, Cairo, Egypt.
6Microbial Biotechnology Department, National Research Centre, Dokki, Cairo, Egypt
7Biochemistry and Molecular Biology Department, Theodor Bilharz Research Institute,Cairo, Egypt.
Abstract
Different benzo[4,5]imidazo[1,2-a]pyrimidine derivatives were synthesized in high purity and yields with short reaction times by the reaction of 2-aminobenzimidazole, aldehydes and active carbonyl compounds in the presence of Silica sulfuric acid/ethylene glycol (SSA/EG) as a catalyst. Cytotoxicity of the synthesized benzo[4,5]imidazo[1,2-a]pyrimidine derivatives 1-6 was carried out against the two human cancer cell lines, hepatocellular carcinoma (HepG2) and breast carcinoma (MCF-7) as well as Vero cells (normal cells).
Keywords
Benzo[4,5]imidazo[1,2-a]pyrimidine; Cytotoxicity; human cancer cell lines; Hepatocellular carcinoma; breast carcinoma
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