CIPROFLOXACIN-LOADED SILVER NANOPARTICLES EFFICACY ON CHRONIC TOXOPLASMOSIS INFECTED MICE | ||
| Journal of the Egyptian Society of Parasitology | ||
| Volume 52, Issue 3, December 2022, Pages 483-490 PDF (1.67 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/jesp.2022.278370 | ||
| Authors | ||
| SAMIA MOSTAFA RASHED; MAYSA AHMED ERAKY; HEMAT SALAH MOHAMED ALI; FAYZA ALI AHMED; EMAN ABDELRAHMAN ABOUOUF | ||
| Department of Medical Parasitology, Faculty of Medicine, Benha University, Egypt | ||
| Abstract | ||
| Toxoplasmosis is one of the commonest health problems especially in immunocompromised patients. The study evaluated the effect of ciprofloxacin loaded on silver nanoparticles in treating mice experimentally infected toxoplasmosis treatment of. This study was conducted on mice infected with (ME 49 Toxoplasma gondii strain). Sixty mice were divided into: GI: 5 non infected non-treated mice (normal control). GII: 10 infected non-treated mice (infected control). GIII: 10 infected mice treated with Spiramycin 100mg/kg (drug controls). GIV: 10 infected mice treated with ciprofloxacin 100mg/kg. GV: 10 infected mice treated with ciprofloxacin loaded silver nano-particles (100mg/kg ciprofloxacin+2.5μg/kg silver nano). GVI: 10 infected mice treated with silver nanoparticles (2.5μg/kg). GVII: 5 non-infected mice treated with silver nanoparticles (2.5μg/kg). Mice were sacrificed 8 weeks (experimental end) and brain and liver from each group were processed for histopathological studies of the cysts numbers, and sizes. | ||
| Keywords | ||
| Albino mice; Toxoplasma gondii; Ciprofloxacin; Silver nanoparticles | ||
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