Assessment of Chronic Kidney Disease in Patients with Non-Alcoholic Fatty Liver Disease (NAFLD); A Single Center Experience | ||
| African Journal of Gastroenterology and Hepatology | ||
| Volume 5, Issue 2, October 2022, Pages 48-63 PDF (542.62 K) | ||
| Document Type: Original Clinical | ||
| DOI: 10.21608/ajgh.2023.178105.1022 | ||
| Authors | ||
| Mona Mohammed Abdelrahman* 1; Shimaa Hemdan2; Mohamed Ezeldin3; Osama Orabi4; Shimaa Rashed5; Ahmed Nagah4 | ||
| 1Tropical medicine and gastroenterology, Faculty of Medicine, Sohag university, Sohag, EGYPT | ||
| 2Medical Biochemistry Department, Faculty of Medicine, Sohag University, Egypt. | ||
| 3Diagnostic and Interventional Radiology Department, Faculty of Medicine, Sohag University, Egypt. | ||
| 4Internal Medicine Department, Faculty of Medicine, Sohag University, Egypt. | ||
| 5Clinical and Chemical Pathology Department, Faculty of Medicine, Sohag University, Egypt. | ||
| Abstract | ||
| Background: Non-alcoholic fatty liver disease (NAFLD) represents a considerable percentage of chronic liver diseases worldwide. The liver is not the only organ affected by NAFLD but also affects other organs such as the cardiovascular system and the kidney. In recent decades, there has been a growing body of evidence linking NAFLD to kidney function. So, the current study aims to assess the percentage of chronic kidney disease (CKD) in NAFLD patients and its link to different stages of hepatic fibrosis. Patients and Methods: A case-control study evaluated 62 non-alcoholic fatty liver disease patients and a control group of 38 volunteers with apparently healthy livers (normal echo pattern by ultrasound). All participants underwent serum creatinine measurement, albumin creatinine ratio in urine, calculation of estimated glomerular filtration rate (eGFR), abdominal ultrasound, and fibroScan examination. Results: The authors showed that the percentage of patients with chronic kidney diseases (patients with GFR less than 60 ml or micro-albuminuria) were significantly higher among NAFLD groups than in healthy controls. There was a significant positive correlation between the albumin creatinine ratio and subcutaneous fat thickness, BMI, and steatosis degrees. The estimated glomerular filtration rate (eGFR) and the age of the patients had a significant negative correlation. In comparison, the eGFR and AST levels had a significant positive correlation. Conclusions: Our results showed that NAFLD substantially raises the risk of getting CKD. | ||
| Keywords | ||
| Non-alcoholic fatty liver disease; Estimated glomerular filtration rate; Microalbuminuria; Chronic kidney disease | ||
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