N- Acetyl Cysteine Versus Hesperidin as a Prophylactic Agent for Lambda - Cyhalothrin Induced Hepatotoxicity in Adult Male Albino Rats: Histological and Immunohistochemical Study | ||
| The Egyptian Journal of Hospital Medicine | ||
| Article 42, Volume 90, Issue 1, January 2023, Pages 282-293 PDF (1.25 M) | ||
| DOI: 10.21608/ejhm.2023.279545 | ||
| Authors | ||
| Nehal Fahmy Shaheen; Mai Hassan Ibrahim | ||
| Department of Anatomy and Embryology, Faculty of Medicine, Benha University, Egypt | ||
| Abstract | ||
| Introduction: Lambda Cyhalothrin (LCT) is greatly used to manage a wide variety of pests present in farming and in home procedures. Aim: The current work was intended to demonstrate structural and functional alterations within the liver subsequent to long-standing exposure to LCT. Protective effect of Hesperidin and N- acetylcysteine was also investigated. Material and methods: 40 adult male albino rats were used in this experiment, and they were split into four equal groups: control, LCT group, rats were received LCT at a dose 61.2mg/kg b. wt. per day by oral gavage for 28 days.LCT + Hesperidin group, rats were given the same dose of LCT with simultaneous oral dosage of HSP at a dose of 100mg/kg b. wt., LCT + N-Acetyl cysteine group at which rats were received the same dose of LCT as the previous 2 groups with simultaneous oral administration of N-acetyl cysteine 150 mg/kg b. wt. The liver underwent a number of biochemical, histological, and immunohistochemical analysis. Results: LCT induced oxidative stress which leads to liver damage (increases MDA / decreases GSH). LCT caused degeneration of hepatocytes and increases inflammatory cells, this is followed by rise in liver markers (AST and ALT). While concurrent administration of Hesperidin and N- Acetyl cysteine during LCT exposure period preserved the architecture of the liver, prevents its damage, reduced oxidative stress and normalized liver function tests. Conclusion: Administration of N –Acetyl cysteine during exposure to the insecticide LCT has a protective effect on the liver more than Hesperidin. | ||
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