AMELIORATIVE ROLE OF ALPHA LIPOIC ACID ON PARACETAMOL INDUCED RENAL TOXICITY AND OXIDATIVE STRESS IN RATS | ||
| The Egyptian Journal of Forensic Sciences and Applied Toxicology | ||
| Article 4, Volume 19, Issue 1, March 2019, Pages 87-106 PDF (1.38 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejfsat.2019.7014.1044 | ||
| Authors | ||
| Sara elsayed kasem* 1; maha Hilal2; Reda mohammed Elsayed3; sheren farrag mahmoud4; amany abbas abdallah5 | ||
| 1forensic medicine and clinical toxicology faculty of medicine sohag university,sohag,Egypt | ||
| 2Forensic Medicine and Clinical Toxicology Department, Faculty of Medicine, Sohag University,sohag, Egypt | ||
| 3Forensic Medicine and Clinical Toxicology Department, Faculty of Medicine, Sohag University, Sohag, Egypt | ||
| 4Pathology Department, Faculty of Medicine, Sohag University, sohag, Egypt | ||
| 5Clinical Pathology Department, Faculty of Medicine, Sohag University,sohag, Egypt | ||
| Abstract | ||
| Background: Paracetamol, is the most widely used over-the-counter analgesic and antipyretic medication in the world, which has no adverse effect at therapeutic dosages. But in high doses causes renal failure. Objectives: The current study was designed to investigate paracetamol toxic effects upon the kidney and oxidative stress after repeated oral dose and evaluate possible protective effect of alpha lipoic acid when co-administered with and after paracetamol. Methods: forty eight white albino rats were divided equally into four groups. Each group was subdivided into two sub groups A & B. Group I received gum acacia suspension. Group II received Alpha lipoic acid (50mg/kg) orally. Group III received paracetamol (1 gm/ kg orally) for 4 weeks. Group IV received paracetamol and alpha lipoic acid at the same doses. Sub groups A were euthanized after 4 weeks, while sub groups B were euthanized after 8 weeks. Blood was collected for evaluation of kidney functions and oxidative stress markers. The kidneys were preserved for histopathological examinations. Results: The study proved that repeated administration of paracetamol induced disturbed kidney functions and oxidative stress. But this toxic effects decline markedly when alpha lipoic acid was co-administered with paracetamol. And more improvement occurs when ALA was administered for another 4 weeks after stoppage of paracetamol. Conclusions: The present study concluded that repeated paracetamol administration has nephrotoxic and oxidative stress effect and alpha lipoic acid has a protective effect against such harmful effects. | ||
| Keywords | ||
| Paracetamol; renal toxicity, oxidative stress, Alpha lipoic acid | ||
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