What is the current Immune Status of HBV Vaccinees in Health Care Workers and Medical Students in Alexandria University, Egypt? | ||
| Egyptian Journal of Medical Microbiology | ||
| Volume 28, Issue 3, July 2019, Pages 1-7 PDF (527.93 K) | ||
| Document Type: New and original researches in the field of Microbiology. | ||
| DOI: 10.21608/ejmm.2019.282765 | ||
| Authors | ||
| Malak A. Abou Khatwa; May M. Raouf* ; Nancy M. Ouf | ||
| Department of Medical Microbiology and Immunology, Microbiology Department, Faculty of Medicine, Alexandria University, Egypt | ||
| Abstract | ||
| Background: Long term immunity of Hepatitis B vaccine, the first vaccine to prevent cancer is a debate. Objective: to assess anti-HBs level in previously vaccinated Health Care Workers (HCWs) and Medical Students (MS). Also, determine the effect of a booster dose on humoral and cell mediated immunity in non seroprotected subjects. Methodology: A cross sectional study included 120 vaccinated HCWs and MS. HBsAg, Anti-HBs level and Interferon γ (IFN-γ) were assessed. Anti-HBs and Interferon γ (IFN-γ) levels were reassessed after a booster dose to non seroprotected subjects. Results: 90% of HCWs and 23.3% of MS were seroprotected. Boosted HCWs and MS showed significant increase in Geometric Mean Titer (GMT) of anti-HBs level (P=0.028, P<0.001 respectively), while IFN-γ mean concentration level (MCL) increased significantly in MS group only (P=0.01). Conclusion: AntiHBs level decreases significantly over time. Long term memory was found to be still intact after a booster dose. | ||
| Keywords | ||
| Hepatitis B virus vaccine; Immune status; Health care workers; Medical students; Booster dose | ||
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