BIOLOGICAL EVALUATION FOR SOME PLANTS USED FOR TREATMENT OF DIABETES AND HYPERLIPIDAEMIA IN RATS | ||
| Journal of Environmental Science | ||
| Article 6, Volume 35, Issue 1, September 2016, Pages 91-111 PDF (721.92 K) | ||
| Document Type: Review Article | ||
| DOI: 10.21608/jes.2016.28306 | ||
| Authors | ||
| El-Tellawy, F. M.1; Moustafa, O. A.2; Freig, Shadia, A.2; Yousef, Ghada, R.3 | ||
| 1Institute of Environmental Studies and Research, Ain shams University | ||
| 2Faculty of Specific Education, Ain shams University. Dietation National | ||
| 3Nutrition Institute, Cairo, Egypt | ||
| Abstract | ||
| This study aimed to decrease blood sugar concentration and hyperlipidemia in rats using dry Cinnamon and fruits Amla. Diabetes can affect many different organ systems in the body and, over time, may lead to serious complications, which can be classified as microvascular or macrovascular. Microvascular complications include nervous system damage (neuropathy), renal system damage (nephropathy) and eye damage (retinopathy). Macrovascular complications include cardiovascular disease, stroke, and peripheral vascular disease, which may lead to bruises or injuries that do not heal, gangrene, and, ultimately, amputation.sixty six Male albino rats Spargue Dawley Strain weighing (200 ± 10 g) were housed in well aerated cages under hygienic condition and fed on basal diet for one week for adaptation. Then rats were divided into three main groups as follows: The first main group (G1) (6 rats) was fed on basal diet (control negative group). The second main group (30 rats) fed on standard diet contained 10% saturated fat to induce hyperlipidemic model, then hyperlipidemic rats were divided into 5sbgroups, each of six rats as follow; Subgroup (G2) fed on basal diet ( positive control group), subgroup (G3) fed on high fat diet containing 1% cinnamon, subgroup (G4) fed on high fat diet containing 1.5% cinnamon, subgroup (G5) fed on high fat diet containing 1% amla and subgroup (G6) fed on high fat diet containing 1.5% amla. The third main group 30 rats were injected with alloxan (120 mg / kg body weight i.p.) to induce diabetes (Dhanabal et al., 2005), then diabetic rats were divided into 5subgroups, each of six rats as follow; subgroup (G7) fed on basal diet as positive control group, subgroup (G8) fed on basal diet containing 1% cinnamon, group(G9) fed on basal diet containing 1.5% cinnamon, subgroup(G10) fed on basal diet containing 1% amla and subgroup(G11) fed on basal diet containing 1.5 % amla. After 4 weeks serum biochemical parameters including glucose, liver function, and blood lipid profile were determined. It could be concluded that, feeding on Cinnamon and fruits Amla led to significant decrement in blood glucose level and lipids of positive group rats compared with diabetic and hyperlipidemic rats fed on basal diet. The reduction of glucose and lipids parameters were observed after one week of feeding gradually till the end of experimental period, also, significantly lower in total cholesterol, triglycerides, and total lipids in comparing to positive diabetic and hyperlipidemic rats fed on basal diet were observed. | ||
| Keywords | ||
| Key words: hyperlipidemia – Diabetes- Cinnamon and fruits Amla | ||
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