Enantioselective synthesis, characterization and biological evaluation of α-alkylated acids | ||
| Delta Journal of Science | ||
| Article 1, Volume 46, Issue 1, February 2023, Pages 1-9 PDF (795.24 K) | ||
| Document Type: Research and Reference | ||
| DOI: 10.21608/djs.2023.184454.1068 | ||
| Authors | ||
| Ahmed Ahmed Noser* 1; Shimaa Gamal Mahmoud2; Hamada Shehata Mandour2; Adel Ibrahim Selim2 | ||
| 1Chemistry department, Faculty of Science, Tanta university, Egypt | ||
| 2chemistry department, faculty of science, tanta university | ||
| Abstract | ||
| all living organisms produce only one enantiomer so we found that all natural compounds are presented in enantiomerically pure form. Asymmetric synthesis is highly spread in pharmaceutical industry because enantiomerically pure drugs are highly applicable. Most of traditional drugs that used for treatment of many diseases are usually undergo racemic modifications of two enantiomers, and the side effect of these drugs is due to presence of the un wanted enantiomer. The asymmetric synthesis has become very important to increase the enantioselectivity of synthesized compounds via different methods. This study demonstrated the enantioselective synthesis of (S)-2-ethylpentanoic acid (5a, b) and (R)- 2-ethylpentanoic acid (5c, d) using quinazolinone derivative (2) as chiral auxiliaries. The enantiomeric excess was determined via HPLC using silica gel column and ranging from 90-98 depending on different factors. Some of the synthesized compounds were examined in-vitro against different types of bacteria and fungi and give a good result. | ||
| Keywords | ||
| enantiomerically pure; Asymmetric synthesis; chiral auxiliaries; enantiomeric excess | ||
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