Synthesis and Anticancer Potentials of 1,8-Naphthyridine Analogues: A Review of Literature | ||
| Egyptian Journal of Chemistry | ||
| Volume 66, Issue 10, October 2023, Pages 331-353 PDF (7.82 M) | ||
| Document Type: Review Articles | ||
| DOI: 10.21608/ejchem.2023.183386.7384 | ||
| Authors | ||
| Nesreen Said Ahmed* 1; Manar Abuzahra2; Mona Sarhan3; Wafaa Abdou Zaghary4 | ||
| 1Department of Therapeutic Chemistry, Pharmaceutical and Drug Industries Division, National Research Center,Cairo, Egypt | ||
| 2Pharmaceutical Chemistry Department, Faculty of Pharmacy, Helwan University, Cairo, Egypt. | ||
| 3Labelled Compounds Department, Hot Lab Centre, Atomic Energy Authority, Cairo 13759, Egypt. | ||
| 4Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Helwan University, Helwan, Cairo, Egypt. | ||
| Abstract | ||
| This review focuses on the potential of 1,8-Naphthyridine derivatives in the chemotherapeutic cancer treatment and highlights significant recent progress in the synthetic development of 1,8-naphthyridines as antitumor agents. The present review provide the classical (Skraup, Doebner-Von-Miller, Gould– Jacob, Meth-Cohn, Friedlander, Pfitzinger, Knorr and Conard Limpach, Combes, Niementowski and Pictet-Spengler) and green approaches (metal free ionic liquid mediated reactions, microwave irradiation reactions) for synthesis of 1,8-naphthyridines. 1,8-naphthyridine derivatives which exert their anticancer activity via several mechanisms like apoptosis inducing agents, cell cycle arrest, topoisomerase I and II inhibitors, tubulin polymerization inhibitors, protein kinase inhibitors, intercalation with DNA, angiogenesis inhibitors, Ras protein inhibitors and telomerase inhibitors, are highlighted with proper synthetic methods, SAR studies and molecular docking. | ||
| Keywords | ||
| 1,8-Naphthyridine; Anticancer agents; Structure-activity relationship; Human cancer cell line; Molecular modelling | ||
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