EUGENOL AMELIORATES PATHOGENIC FEATURES IN EXPERIMENTAL MODEL OF NAFLD IN RATS | ||
| Al-Azhar Journal of Pharmaceutical Sciences | ||
| Article 10, Volume 56, Issue 2, September and October 2017, Pages 115-122 PDF (577.64 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ajps.2017.28465 | ||
| Author | ||
| Maryam Azab | ||
| Demonstrator, Department of Drugs and Toxicology, Faculty of Pharmacy, Egyptian-Russian University | ||
| Abstract | ||
| Background: Nonalcoholic fatty liver disease (NAFLD) is emerging one of the major causes of chronic liver damage that includes a wide spectrum of liver injury ranging from steatosis to steatohepatitis evolving to fibrosis. Aim: This study was designed to evaluate the possible effect of EUG on NAFLD induced by high fat cholesterol diet. Methods:Rats were fed either normal rat chow diet (control) or high fat cholesterol diet and both received olive oil (10 mg/kg) for eight weeks to induce NAFLD model. Eugenol (10 mg/kg) was administrated to rats by oral intubation 3 times weekly for 8 weeks. Results:Our results showed that EUG significantly ameliorated the histopathological lesions induced by HFCD. Furthermore, HFCD induced a significant elevation in liver enzymes (alanine aminotransferase (ALT) and aspartate aminotransferase (AST)). This was significantly attenuated by EUG co-treatment. Conclusion:These findings indicate that EUG possess es a marked role in modulation of NAFLD. | ||
| Keywords | ||
| eugenol; NAFLD | ||
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