Gaballah, A., Shawky, S., Elsawaf, G., Shamsia, M., Al Makdad, A., Abd Elrahman, M., Osman, N., Islim, H., Al-haifi, A., Kader, O. (2018). Virological Profiles of HBV and HCV in Hepatocellular Carcinoma in Egypt and Yemen. test, 27(2), 7-17. doi: 10.21608/ejmm.2018.285501
Ahmed Gaballah; Sherine Shawky; Gamal Elsawaf; Mohamed Shamsia; Abdulsalam Al Makdad; Mohamed Abd Elrahman; Nermin A. Osman; Hanadi Islim; Abdelrahman Al-haifi; Ola Kader. "Virological Profiles of HBV and HCV in Hepatocellular Carcinoma in Egypt and Yemen". test, 27, 2, 2018, 7-17. doi: 10.21608/ejmm.2018.285501
Gaballah, A., Shawky, S., Elsawaf, G., Shamsia, M., Al Makdad, A., Abd Elrahman, M., Osman, N., Islim, H., Al-haifi, A., Kader, O. (2018). 'Virological Profiles of HBV and HCV in Hepatocellular Carcinoma in Egypt and Yemen', test, 27(2), pp. 7-17. doi: 10.21608/ejmm.2018.285501
Gaballah, A., Shawky, S., Elsawaf, G., Shamsia, M., Al Makdad, A., Abd Elrahman, M., Osman, N., Islim, H., Al-haifi, A., Kader, O. Virological Profiles of HBV and HCV in Hepatocellular Carcinoma in Egypt and Yemen. test, 2018; 27(2): 7-17. doi: 10.21608/ejmm.2018.285501

Virological Profiles of HBV and HCV in Hepatocellular Carcinoma in Egypt and Yemen

Egyptian Journal of Medical Microbiology
Volume 27, Issue 2, April 2018, Pages 7-17    PDF (475.57 K)
Document Type: New and original researches in the field of Microbiology.
DOI: 10.21608/ejmm.2018.285501
Authors
Ahmed Gaballah* 1; Sherine Shawky1; Gamal Elsawaf1; Mohamed Shamsia2; Abdulsalam Al Makdad3; Mohamed Abd Elrahman4; Nermin A. Osman5; Hanadi Islim6; Abdelrahman Al-haifi2; Ola Kader1
1Microbiology Department, Medical Research Institute, Alexandria University, Egypt
2Hepatology Department, Medical research Institute, Alexandria University, Egypt
3Diseases of liver and digestive system department, Dhamar University, Yemen
4Clinical pathology department, Medical Military Academy, Alexandria, Egypt
5Biomedical informatics and Medical Statistics Department, Medical Research Institute, Alexandria University, Egypt
6Faculty of Pharmacy and drug Manufacturing, Pharos University
Abstract
Background: Hepatocellular carcinoma (HCC) is one of the very frequent malignancies that has poor prognosis. Chronic hepatitis B is the most important risk factor in the world particularly in developping countries. In developed world, HCC occurs in the background of chronic infection with HCV or alcohol abuse. Several factors affects the development of HCC in chronic hepatitis patients including viral genotype. Objectives: The aim of this study was to determine HCV and HBV viral profile in Egyptian and Yemeni HCC patients. Additionally, HCV and HBV were genotyped to investigate any possible correlation with HCC development. Methodology: Thirty HCC Egyptian patients admitted to the Hepatology Unit, Medical Research Institute, Alexandria University and thirty HCC Yemeni patients attending the oncology center in Al-Gomhory hospital in Sanaa have been enrolled in this study. Hepatitis B surface Ag (HBs-Ag) was not detected in Egyptian HCC patients but in 36.7% of Yemeni HCC patients. On the other hand, anti-HCV antibodies were detected in 93.3% of the Egyptian HCC patients and in 16.7% only in Yemeni patients. HBV genotyping by direct sequencing of pol gene showed 11 cases of genotype D and 1 case of genotype E among HCC Yemeni patients. HCV genotyping by sequencing of NS5b and 5'UTR showed 21 cases of genotype 4 and 2 cases of genotype 1 and genotype 2 among Egyptian HCC patients. Conclusion: From the current study HCC appears to be significantly associated with HBV and HCV chronic infections in Yemen and Egypt respectively. In Egypt, occult HBV co-infection might escalate the danger of HCC development among HCV patients.
Keywords
Hepatocellular Carcinoma (HCC); Hepatitis B virus (HBV); Hepatitis C virus (HCV); Genotyping
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