El-hawary, H., El –Mosallamy, W., Mahmoud, M., Emam, S., Abd Elazim, I. (2018). Role of IL17A in Candidemic Patients in ICU at Benha University Hospital. test, 27(3), 7-12. doi: 10.21608/ejmm.2018.285583
Hagar G . El-hawary; Wafaa A. El –Mosallamy; Mahmoud Abd El-sabour Mahmoud; Sherin M. Emam; Ihab S. Abd Elazim. "Role of IL17A in Candidemic Patients in ICU at Benha University Hospital". test, 27, 3, 2018, 7-12. doi: 10.21608/ejmm.2018.285583
El-hawary, H., El –Mosallamy, W., Mahmoud, M., Emam, S., Abd Elazim, I. (2018). 'Role of IL17A in Candidemic Patients in ICU at Benha University Hospital', test, 27(3), pp. 7-12. doi: 10.21608/ejmm.2018.285583
El-hawary, H., El –Mosallamy, W., Mahmoud, M., Emam, S., Abd Elazim, I. Role of IL17A in Candidemic Patients in ICU at Benha University Hospital. test, 2018; 27(3): 7-12. doi: 10.21608/ejmm.2018.285583

Role of IL17A in Candidemic Patients in ICU at Benha University Hospital

Egyptian Journal of Medical Microbiology
Volume 27, Issue 3, July 2018, Pages 7-12    PDF (414.55 K)
Document Type: New and original researches in the field of Microbiology.
DOI: 10.21608/ejmm.2018.285583
Authors
Hagar G . El-hawary* 1; Wafaa A. El –Mosallamy1; Mahmoud Abd El-sabour Mahmoud1; Sherin M. Emam1; Ihab S. Abd Elazim2
1Department of Medical Microbiology and Immunology, Faculty of medicine - Benha University
2Department of Anesthesia and ICU Faculty of Medicine - Benha University
Abstract
Background: IL-17 plays a major protective role against fungal infection in mice and humans. Genetic defects involving IL-17 increase the susceptibility to candidiasis. Objective: This study aimed at assessing the association between serum Interleukin-17A (IL17A) and candida infection in Intensive Care Unit patients with candidemia versus non-candidemic patients. Methodology: 90 individuals were included; 60 ICU patients, divided into 2 groups; group1: 30 patients with Candidemia, group 2: 30 patients with Candida in sputum and/or urine samples and 30 apparently healthy as a control group. All enrolled individuals underwent history taking, physical examination, laboratory assessment for Candida albicans infection and serum IL-17A. Results: IL17A level was significantly high among candidemia group (0.24  0.10 pg/ml) followed by group of candida in urine and sputum (0.08  0.02 pg/ml) (P-value <0.001). Conclusion: There was an association between IL-17A levels and candidemia suggesting its predictive value for a forthcoming invasive candidiasis.
Keywords
Interleukin-17; candidemia; Intensive care units
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