Abd El Ghafar, D., Elzayyadi, I., Abd Allah, A., Gaafar, S., Bakr, E. (2023). Impact of HCV Eradication on Rheumatoid Arthritis Activity in Rheumatoid Arthritis Patients with Concomitant HCV Infection. test, 29(5), 1440-1447. doi: 10.21608/zumj.2023.182913.2706
Dina Abd El Ghafar; Islam Elzayyadi; Aya Abd Allah; Sherine Gaafar; Eman Bakr. "Impact of HCV Eradication on Rheumatoid Arthritis Activity in Rheumatoid Arthritis Patients with Concomitant HCV Infection". test, 29, 5, 2023, 1440-1447. doi: 10.21608/zumj.2023.182913.2706
Abd El Ghafar, D., Elzayyadi, I., Abd Allah, A., Gaafar, S., Bakr, E. (2023). 'Impact of HCV Eradication on Rheumatoid Arthritis Activity in Rheumatoid Arthritis Patients with Concomitant HCV Infection', test, 29(5), pp. 1440-1447. doi: 10.21608/zumj.2023.182913.2706
Abd El Ghafar, D., Elzayyadi, I., Abd Allah, A., Gaafar, S., Bakr, E. Impact of HCV Eradication on Rheumatoid Arthritis Activity in Rheumatoid Arthritis Patients with Concomitant HCV Infection. test, 2023; 29(5): 1440-1447. doi: 10.21608/zumj.2023.182913.2706

Impact of HCV Eradication on Rheumatoid Arthritis Activity in Rheumatoid Arthritis Patients with Concomitant HCV Infection

Zagazig University Medical Journal
Article 26, Volume 29, Issue 5, September and October 2023, Pages 1440-1447    PDF (460.8 K)
Document Type: Original Article
DOI: 10.21608/zumj.2023.182913.2706
Authors
Dina Abd El Ghafar* 1; Islam Elzayyadi2; Aya Abd Allah3; Sherine Gaafar4; Eman Bakr4
1Rheumatology and rehabilitation department. faculty of medicine, Mansoura university, Mansoura , Egypt
2internal medicine department, gastroenterology and hepatology unit, Faculty of medicine, Mansoura university, Mansoura, Egypt
3Public health and preventive medicine department, Faculty of medicine, Mansoura university, Mansoura, Egypt
4Rheumatology and rehabilitation department, Faculty of medicine, Mansoura university, Mansoura, Egypt
Abstract
ABSTRACT
Background and aim of work: Rheumatoid arthritis (RA) patients with concomitant hepatitis C virus (HCV) infection tend to have higher disease activity than patients with no HCV. In this retrospective study, we aimed to explore the potential outcome of elimination of HCV on RA disease activity in the patients with comorbidity of RA and HCV infection.

Methods: This is a retrospective study. The medical records of 55 RA patients with concomitant HCV infection were reviewed. RA clinical and laboratory parameters of RA activity and disease activity score-28 (DAS28) were obtained from the medical records before the initiation of the anti-viral treatment and 12-weeks after completing antiviral therapy for HCV.
Results: After treatment, the sustained virological response 12-weeks (SVR12) was achieved in 83.6% of the patients. Good and moderate response based on EULAR response criteria was achieved in 76% of the RA patients. In RA patients achieved SVR12, there was a significant post-treatment decline in the RA activity parameters including morning stiffness duration (p
Keywords
Hepatitis C virus infection; rheumatoid arthritis; disease activity score
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