Impact of Cytomegalovirus (CMV) Infection on Renal Transplantation and Graft Rejection. | ||
| GEGET | ||
| Volume 17, Issue 2, December 2022, Pages 31-40 PDF (232.12 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/geget.2022.287744 | ||
| Authors | ||
| Hanan Abdel Aziz Ahmed* 1; Fatina I Fadel1; Emad E Ghobrial1; Aliaa Ali2 | ||
| 1Department of Pediatrics, Kasr Al Ainy, School of Medicine, Cairo University, Cairo, Egypt. | ||
| 2Department of Pediatrics, Ministry of Health, Egypt | ||
| Abstract | ||
| Introduction: cytomegalovirus (CMV) infection is a common problem among kidney transplant patients. It can affect patient morbidity and graft survival. It is also associated with acute and chronic graft rejection. Aim of the study: The aim of this work is to show the prevalence and natural course post-kidney transplantation of CMV infection and the effect of CMV on patient morbidity and mortality. Methods: This cohort study was performed at Children Hospital, Cairo University during the period from May 2016 to January 2018, including thirty pediatric renal transplanted patients diagnosed as end-stage renal disease (ESRD) and had kidney transplantation. Patients were divided into two groups; patients' group with CMV infection and control group without CMV infection. CMV infection was diagnosed by quantitative polymerase chain reaction. Results: Patients were divided according to PCR as CMV positive group [8 patients (26.7%)] and negative group [22 patients (73.3%)]. There was a statistically significant difference between 2 studied groups as regard chest infection (p= 0.019), height (p= 0.003) and hemodialysis duration (p= 0.022) in the CMV positive patients. Urinary tract infection was the major co-morbidity in the 2 groups (59.1% in the negative patients and 75% in the positive patients), followed by hypertension (18.2% in the negative patients and 37.5% in the positive group). No statistically significant difference in the rejection episodes in both groups. Conclusion: CMV disease can increase the risk of infections like chest infection and UTI and a risk factor for cardiovascular diseases as hypertension | ||
| Keywords | ||
| CMV; renal transplantation; children | ||
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