Abdulhafith, A., Siam, A., Mohammed, A., Risha, A. (2023). Diagnostic Utility of Serum Copeptin Level in Children with Febrile Seizures. test, 90(2), 3022-3026. doi: 10.21608/ejhm.2023.288377
Ammar Ali Ammar Abdulhafith; Ahmed Galal Siam; Ahmed Abdel Sabour Mohammed; AMR I. Risha. "Diagnostic Utility of Serum Copeptin Level in Children with Febrile Seizures". test, 90, 2, 2023, 3022-3026. doi: 10.21608/ejhm.2023.288377
Abdulhafith, A., Siam, A., Mohammed, A., Risha, A. (2023). 'Diagnostic Utility of Serum Copeptin Level in Children with Febrile Seizures', test, 90(2), pp. 3022-3026. doi: 10.21608/ejhm.2023.288377
Abdulhafith, A., Siam, A., Mohammed, A., Risha, A. Diagnostic Utility of Serum Copeptin Level in Children with Febrile Seizures. test, 2023; 90(2): 3022-3026. doi: 10.21608/ejhm.2023.288377

Diagnostic Utility of Serum Copeptin Level in Children with Febrile Seizures

The Egyptian Journal of Hospital Medicine
Article 156, Volume 90, Issue 2, January 2023, Pages 3022-3026    PDF (296.27 K)
Document Type: Original Article
DOI: 10.21608/ejhm.2023.288377
Authors
Ammar Ali Ammar Abdulhafith* ; Ahmed Galal Siam; Ahmed Abdel Sabour Mohammed; AMR I. Risha
Abstract
Introduction: Febrile seizuresare the most frequent convulsive episode in children, involving 2-5% of those between the ages of six months and five years. Arginine-vasopressin (AVP), a pituitary hormone, has been shown to play a role in response to fever and convulsions, affecting the thermoregulatory system. Copeptin's C-terminal region has been identified as a reliable predictor of AVP production. Objective: The aim of the current study was to assess serum copeptin's diagnostic utility in febrile seizures.
Patients and methods: A case-control study was conducted at Zagazig University’s Emergency Room and Neurology Unit of Children’s Hospital. A total of 46 patients were recruited and were divided into two groups; Febrile seizure group included 23 patients and febrile without seizures group included 23 patients.
Results: There is significant higher copeptin value in febrile seizures group compared to febrile control without seizures group (P<0.05). Copeptin in diagnose seizure patients in febrile patients revealed a sensitivity of 82.6%, a specificity of 78.3% and 80.4% accuracy at a cutoff value >75 pg/ml.
Conclusion: Serum copeptin can tell the difference between a febrile seizure and a febrile without a seizure.Serum copeptin at cut off value >75pg/ml was a good marker for detecting seizures in febrile patients.Serum copeptin performed adequately as a diagnostic tool, highlighting its potential role in the febrile seizure diagnostic algorithm.
 
Keywords
Serum Copeptin; Febrile Seizures; Children; Case control study; Zagazig University
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