Abosedera, D., Abd Elfatah, E., Tammam, O., Badr, O., Refaey, M. (2022). Cytotoxic Activity of Asphodelus Microcarpus as Amain Food of Spalax Leucodon Egyptiacus. test, 1(1), 156-166. doi: 10.21608/ijesr.2022.288687
Dalia Abosedera; Emara Abd Elfatah; Omar Tammam; Osama Badr; Mohamed Refaey. "Cytotoxic Activity of Asphodelus Microcarpus as Amain Food of Spalax Leucodon Egyptiacus". test, 1, 1, 2022, 156-166. doi: 10.21608/ijesr.2022.288687
Abosedera, D., Abd Elfatah, E., Tammam, O., Badr, O., Refaey, M. (2022). 'Cytotoxic Activity of Asphodelus Microcarpus as Amain Food of Spalax Leucodon Egyptiacus', test, 1(1), pp. 156-166. doi: 10.21608/ijesr.2022.288687
Abosedera, D., Abd Elfatah, E., Tammam, O., Badr, O., Refaey, M. Cytotoxic Activity of Asphodelus Microcarpus as Amain Food of Spalax Leucodon Egyptiacus. test, 2022; 1(1): 156-166. doi: 10.21608/ijesr.2022.288687

Cytotoxic Activity of Asphodelus Microcarpus as Amain Food of Spalax Leucodon Egyptiacus

International Journal of Environmental Studies and Researches
Article 14, Volume 1, Issue 1, June 2022, Pages 156-166    PDF (614.42 K)
Document Type: Original scientific articles
DOI: 10.21608/ijesr.2022.288687
Authors
Dalia Abosedera1; Emara Abd Elfatah2; Omar Tammam* 1; Osama Badr3; Mohamed Refaey3
1Environmental Studies and Research Institute, University of Sadat City
2Biotechnology Institute (GEBRI), University of Sadat City, Sadat City
3Faculty of Pharmacy, University of Sadat City, Menoufia
Abstract
 
Abstract
The present study aimed to know if the food of Spalax leucodon Egyptiacus has a role in its resistance to cancer. In vitro cytotoxic effects of the main food of Spalax leucodon Egyptiacus as a daily meal that was Asphodelus microcarpus which planted in Marsa Matroh governorate Eldabaa region .We use two fractions of the extract of this plant (Ethyl Acetate &Precipitate), cell viability and cytotoxic activities were assessed using The sulforhodamine B( SRB) assay, IC50 values were estimated for the A375 melanoma. We revealed that the IC50 for the A375 melanoma was 83 ug/ml for Ethyl Acetate (EtOAc) fraction, 65ug/ml for Precipitate (PPT) fraction after 48 hours of treatment. Asphodelus microcarpus  fraction has considerable cytotoxic effects on the human melanoma cell line , its show effect on cell line A375 human melanoma ,further studies  are required to  emphasizes the relation between resistant cancer in Spalax leucodon Egyptiacus and its main food.
 
Keywords
Keywords: Asphodelus microcarpus; A375 Melanoma Cell Line; Cytotoxicity; Spalax leucodon Egyptiacus
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